| http://purl.uniprot.org/citations/31209033 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31209033 | http://www.w3.org/2000/01/rdf-schema#comment | "βII-spectrin is the generally expressed member of the β-spectrin family of elongated polypeptides that form micrometer-scale networks associated with plasma membranes. We addressed in vivo functions of βII-spectrin in neurons by knockout of βII-spectrin in mouse neural progenitors. βII-spectrin deficiency caused severe defects in long-range axonal connectivity and axonal degeneration. βII-spectrin-null neurons exhibited reduced axon growth, loss of actin-spectrin-based periodic membrane skeleton, and impaired bidirectional axonal transport of synaptic cargo. We found that βII-spectrin associates with KIF3A, KIF5B, KIF1A, and dynactin, implicating spectrin in the coupling of motors and synaptic cargo. βII-spectrin required phosphoinositide lipid binding to promote axonal transport and restore axon growth. Knockout of ankyrin-B (AnkB), a βII-spectrin partner, primarily impaired retrograde organelle transport, while double knockout of βII-spectrin and AnkB nearly eliminated transport. Thus, βII-spectrin promotes both axon growth and axon stability through establishing the actin-spectrin-based membrane-associated periodic skeleton as well as enabling axonal transport of synaptic cargo."xsd:string |
| http://purl.uniprot.org/citations/31209033 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1820649116"xsd:string |
| http://purl.uniprot.org/citations/31209033 | http://purl.uniprot.org/core/author | "Zhou R."xsd:string |
| http://purl.uniprot.org/citations/31209033 | http://purl.uniprot.org/core/author | "Zhuang X."xsd:string |
| http://purl.uniprot.org/citations/31209033 | http://purl.uniprot.org/core/author | "Bennett V."xsd:string |
| http://purl.uniprot.org/citations/31209033 | http://purl.uniprot.org/core/author | "Lorenzo D.N."xsd:string |
| http://purl.uniprot.org/citations/31209033 | http://purl.uniprot.org/core/author | "Mohler P.J."xsd:string |
| http://purl.uniprot.org/citations/31209033 | http://purl.uniprot.org/core/author | "Badea A."xsd:string |
| http://purl.uniprot.org/citations/31209033 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31209033 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/31209033 | http://purl.uniprot.org/core/pages | "15686-15695"xsd:string |
| http://purl.uniprot.org/citations/31209033 | http://purl.uniprot.org/core/title | "betaII-spectrin promotes mouse brain connectivity through stabilizing axonal plasma membranes and enabling axonal organelle transport."xsd:string |
| http://purl.uniprot.org/citations/31209033 | http://purl.uniprot.org/core/volume | "116"xsd:string |
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