http://purl.uniprot.org/citations/31210305 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/31210305 | http://www.w3.org/2000/01/rdf-schema#comment | "ObjectiveTo clarify the influence of microRNA-93-5p (miRNA-93-5p) on biological behaviors of gastric cancer (GC) cells and its regulatory effect on Hippo pathway.Materials and methodsSGC-7901 and HGC-27 cells were used for establishing miRNA-93-5p overexpression and downregulation model through transfection of miRNA-93-5p mimics or inhibitor, respectively. Relative levels of genes in Hippo pathway were determined in GC cells transfected with miRNA-93-5p mimics or inhibitor by quantitative Real-time polymerase chain reaction (qRT-PCR). Regulatory effects of miRNA-93-5p on proliferative, migratory and invasive abilities of GC cells were evaluated by cell counting kit-8 (CCK-8), colony formation and transwell assay, respectively.ResultsMiRNA-93-5p was markedly upregulated by transfection of miRNA-93-5p mimics into SGC-7901 cells, which was downregulated by transfection of miRNA-93-5p inhibitor into HGC-27 cells. Overexpression of miRNA-93-5p accelerated GC cells to proliferate, migrate and invade. Meanwhile, miRNA-93-5p overexpression in GC cells upregulated downstream genes in Hippo pathway, including CDX2, FOXM1 and CTGF.ConclusionsMiRNA-93-5p enhances proliferative, migratory and invasive abilities of GC cells by activating Hippo pathway, which may serve as a diagnostic and therapeutic target for GC."xsd:string |
http://purl.uniprot.org/citations/31210305 | http://purl.org/dc/terms/identifier | "doi:10.26355/eurrev_201906_18058"xsd:string |
http://purl.uniprot.org/citations/31210305 | http://purl.uniprot.org/core/author | "Han D."xsd:string |
http://purl.uniprot.org/citations/31210305 | http://purl.uniprot.org/core/author | "Meng H."xsd:string |
http://purl.uniprot.org/citations/31210305 | http://purl.uniprot.org/core/author | "Zhang C.Y."xsd:string |
http://purl.uniprot.org/citations/31210305 | http://purl.uniprot.org/core/author | "Li Y.Y."xsd:string |
http://purl.uniprot.org/citations/31210305 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
http://purl.uniprot.org/citations/31210305 | http://purl.uniprot.org/core/name | "Eur Rev Med Pharmacol Sci"xsd:string |
http://purl.uniprot.org/citations/31210305 | http://purl.uniprot.org/core/pages | "4763-4769"xsd:string |
http://purl.uniprot.org/citations/31210305 | http://purl.uniprot.org/core/title | "MiRNA-93-5p promotes the biological progression of gastric cancer cells via Hippo signaling pathway."xsd:string |
http://purl.uniprot.org/citations/31210305 | http://purl.uniprot.org/core/volume | "23"xsd:string |
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