| http://purl.uniprot.org/citations/31211872 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31211872 | http://www.w3.org/2000/01/rdf-schema#comment | "Isocitrate dehydrogenases (IDHs) are metabolic enzymes that are mutated in several cancers, resulting in overproduction of d-2-hydroxyglutarate (D-2HG). However, the signalling pathways and factors that regulate mutant IDHs or their metabolites remain elusive. Here, we report that in synchronized cells and cells treated with anti-mitotic agents, wild-type and mutant IDH proteins are induced maximally in G2/M. Moreover, mutant IDH1-expressing cells arrested in G2/M harbour high D2HG levels. Genetic or pharmacological perturbation of Forkhead box protein M1 (FOXM1) abrogates the levels of IDH1 mRNA, protein and D2HG in G2/M. Conversely, overexpression of FOXM1 or hyperactive FOXM1 activates the IDH1 promoter and increases the abundance of its protein levels. In summary, our results show that in G2/M, higher D2HG levels are dependent on FOXM1-mediated transcription of IDH1."xsd:string |
| http://purl.uniprot.org/citations/31211872 | http://purl.org/dc/terms/identifier | "doi:10.1002/1873-3468.13500"xsd:string |
| http://purl.uniprot.org/citations/31211872 | http://purl.uniprot.org/core/author | "Jain N."xsd:string |
| http://purl.uniprot.org/citations/31211872 | http://purl.uniprot.org/core/author | "Bala Bhaskara Rao K."xsd:string |
| http://purl.uniprot.org/citations/31211872 | http://purl.uniprot.org/core/author | "Katragunta K."xsd:string |
| http://purl.uniprot.org/citations/31211872 | http://purl.uniprot.org/core/author | "Sarma U.M."xsd:string |
| http://purl.uniprot.org/citations/31211872 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31211872 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/31211872 | http://purl.uniprot.org/core/pages | "2177-2193"xsd:string |
| http://purl.uniprot.org/citations/31211872 | http://purl.uniprot.org/core/title | "Abundance of d-2-hydroxyglutarate in G2/M is determined by FOXM1 in mutant IDH1-expressing cells."xsd:string |
| http://purl.uniprot.org/citations/31211872 | http://purl.uniprot.org/core/volume | "593"xsd:string |
| http://purl.uniprot.org/citations/31211872 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31211872 |
| http://purl.uniprot.org/citations/31211872 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31211872 |
| http://purl.uniprot.org/uniprot/#_A0A0D9SFF0-mappedCitation-31211872 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31211872 |
| http://purl.uniprot.org/uniprot/#_A0A024R3Y6-mappedCitation-31211872 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31211872 |
| http://purl.uniprot.org/uniprot/#_A0A0A0U6N4-mappedCitation-31211872 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31211872 |
| http://purl.uniprot.org/uniprot/#_A0A2P9DTZ0-mappedCitation-31211872 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31211872 |
| http://purl.uniprot.org/uniprot/#_A0A2P9DTZ1-mappedCitation-31211872 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31211872 |
| http://purl.uniprot.org/uniprot/#_A0A2P9DTZ8-mappedCitation-31211872 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31211872 |
| http://purl.uniprot.org/uniprot/#_B2R5M8-mappedCitation-31211872 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31211872 |
| http://purl.uniprot.org/uniprot/#_B4DXS4-mappedCitation-31211872 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31211872 |
| http://purl.uniprot.org/uniprot/#_A8K591-mappedCitation-31211872 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31211872 |
| http://purl.uniprot.org/uniprot/#_O75874-mappedCitation-31211872 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31211872 |
| http://purl.uniprot.org/uniprot/#_Q08050-mappedCitation-31211872 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31211872 |