| http://purl.uniprot.org/citations/31227602 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31227602 | http://www.w3.org/2000/01/rdf-schema#comment | "Posttranscriptional regulation plays a crucial role in shaping gene expression. During the maternal-to-zygotic transition (MZT), thousands of maternal transcripts are regulated. However, how different cis-elements and trans-factors are integrated to determine mRNA stability remains poorly understood. Here, we show that most transcripts are under combinatorial regulation by multiple decay pathways during zebrafish MZT. By using a massively parallel reporter assay, we identified cis-regulatory sequences in the 3' UTR, including U-rich motifs that are associated with increased mRNA stability. In contrast, miR-430 target sequences, UAUUUAUU AU-rich elements (ARE), CCUC, and CUGC elements emerged as destabilizing motifs, with miR-430 and AREs causing mRNA deadenylation upon genome activation. We identified trans-factors by profiling RNA-protein interactions and found that poly(U)-binding proteins are preferentially associated with 3' UTR sequences and stabilizing motifs. We show that this activity is antagonized by C-rich motifs and correlated with protein binding. Finally, we integrated these regulatory motifs into a machine learning model that predicts reporter mRNA stability in vivo."xsd:string |
| http://purl.uniprot.org/citations/31227602 | http://purl.org/dc/terms/identifier | "doi:10.1101/gr.245159.118"xsd:string |
| http://purl.uniprot.org/citations/31227602 | http://purl.uniprot.org/core/author | "Walther T.C."xsd:string |
| http://purl.uniprot.org/citations/31227602 | http://purl.uniprot.org/core/author | "Lee M.T."xsd:string |
| http://purl.uniprot.org/citations/31227602 | http://purl.uniprot.org/core/author | "Christiano R."xsd:string |
| http://purl.uniprot.org/citations/31227602 | http://purl.uniprot.org/core/author | "Lau S."xsd:string |
| http://purl.uniprot.org/citations/31227602 | http://purl.uniprot.org/core/author | "Vejnar C.E."xsd:string |
| http://purl.uniprot.org/citations/31227602 | http://purl.uniprot.org/core/author | "Tavazoie S."xsd:string |
| http://purl.uniprot.org/citations/31227602 | http://purl.uniprot.org/core/author | "Musaev D."xsd:string |
| http://purl.uniprot.org/citations/31227602 | http://purl.uniprot.org/core/author | "Cifuentes D."xsd:string |
| http://purl.uniprot.org/citations/31227602 | http://purl.uniprot.org/core/author | "Giraldez A.J."xsd:string |
| http://purl.uniprot.org/citations/31227602 | http://purl.uniprot.org/core/author | "Takacs C.M."xsd:string |
| http://purl.uniprot.org/citations/31227602 | http://purl.uniprot.org/core/author | "Beaudoin J.D."xsd:string |
| http://purl.uniprot.org/citations/31227602 | http://purl.uniprot.org/core/author | "Yartseva V."xsd:string |
| http://purl.uniprot.org/citations/31227602 | http://purl.uniprot.org/core/author | "Darwich-Codore H."xsd:string |
| http://purl.uniprot.org/citations/31227602 | http://purl.uniprot.org/core/author | "Oikonomou P."xsd:string |
| http://purl.uniprot.org/citations/31227602 | http://purl.uniprot.org/core/author | "Stoeckius M."xsd:string |
| http://purl.uniprot.org/citations/31227602 | http://purl.uniprot.org/core/author | "Abdel Messih M."xsd:string |
| http://purl.uniprot.org/citations/31227602 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31227602 | http://purl.uniprot.org/core/name | "Genome Res"xsd:string |
| http://purl.uniprot.org/citations/31227602 | http://purl.uniprot.org/core/pages | "1100-1114"xsd:string |
| http://purl.uniprot.org/citations/31227602 | http://purl.uniprot.org/core/title | "Genome wide analysis of 3' UTR sequence elements and proteins regulating mRNA stability during maternal-to-zygotic transition in zebrafish."xsd:string |
| http://purl.uniprot.org/citations/31227602 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/31227602 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31227602 |