| http://purl.uniprot.org/citations/31227701 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31227701 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31227701 | http://www.w3.org/2000/01/rdf-schema#comment | "Eukaryotic ribosomes are synthesized in a hierarchical process driven by a plethora of assembly factors, but how maturation events at physically distant sites on pre-ribosomes are coordinated is poorly understood. Using functional analyses and cryo-EM, we show that ribosomal protein Rps20 orchestrates communication between two multi-step maturation events across the pre-40S subunit. Our study reveals that during pre-40S maturation, formation of essential contacts between Rps20 and Rps3 permits assembly factor Ltv1 to recruit the Hrr25 kinase, thereby promoting Ltv1 phosphorylation. In parallel, a deeply buried Rps20 loop reaches to the opposite pre-40S side, where it stimulates Rio2 ATPase activity. Both cascades converge to the final maturation steps releasing Rio2 and phosphorylated Ltv1. We propose that conformational proofreading exerted via Rps20 constitutes a checkpoint permitting assembly factor release and progression of pre-40S maturation only after completion of all earlier maturation steps."xsd:string |
| http://purl.uniprot.org/citations/31227701 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-019-10678-z"xsd:string |
| http://purl.uniprot.org/citations/31227701 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-019-10678-z"xsd:string |
| http://purl.uniprot.org/citations/31227701 | http://purl.uniprot.org/core/author | "Ferreira-Cerca S."xsd:string |
| http://purl.uniprot.org/citations/31227701 | http://purl.uniprot.org/core/author | "Ferreira-Cerca S."xsd:string |
| http://purl.uniprot.org/citations/31227701 | http://purl.uniprot.org/core/author | "Pertschy B."xsd:string |
| http://purl.uniprot.org/citations/31227701 | http://purl.uniprot.org/core/author | "Pertschy B."xsd:string |
| http://purl.uniprot.org/citations/31227701 | http://purl.uniprot.org/core/author | "Kressler D."xsd:string |
| http://purl.uniprot.org/citations/31227701 | http://purl.uniprot.org/core/author | "Kressler D."xsd:string |
| http://purl.uniprot.org/citations/31227701 | http://purl.uniprot.org/core/author | "Rinaldi D."xsd:string |
| http://purl.uniprot.org/citations/31227701 | http://purl.uniprot.org/core/author | "Rinaldi D."xsd:string |
| http://purl.uniprot.org/citations/31227701 | http://purl.uniprot.org/core/author | "Gleizes P.E."xsd:string |
| http://purl.uniprot.org/citations/31227701 | http://purl.uniprot.org/core/author | "Gleizes P.E."xsd:string |
| http://purl.uniprot.org/citations/31227701 | http://purl.uniprot.org/core/author | "Enne T."xsd:string |
| http://purl.uniprot.org/citations/31227701 | http://purl.uniprot.org/core/author | "Enne T."xsd:string |
| http://purl.uniprot.org/citations/31227701 | http://purl.uniprot.org/core/author | "Mitterer V."xsd:string |
| http://purl.uniprot.org/citations/31227701 | http://purl.uniprot.org/core/author | "Mitterer V."xsd:string |
| http://purl.uniprot.org/citations/31227701 | http://purl.uniprot.org/core/author | "Murat G."xsd:string |
| http://purl.uniprot.org/citations/31227701 | http://purl.uniprot.org/core/author | "Murat G."xsd:string |
| http://purl.uniprot.org/citations/31227701 | http://purl.uniprot.org/core/author | "Omanic H."xsd:string |
| http://purl.uniprot.org/citations/31227701 | http://purl.uniprot.org/core/author | "Omanic H."xsd:string |
| http://purl.uniprot.org/citations/31227701 | http://purl.uniprot.org/core/author | "Plisson-Chastang C."xsd:string |
| http://purl.uniprot.org/citations/31227701 | http://purl.uniprot.org/core/author | "Plisson-Chastang C."xsd:string |