| http://purl.uniprot.org/citations/31230402 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31230402 | http://www.w3.org/2000/01/rdf-schema#comment | "A number of calmodulin (CaM) mutations cause severe cardiac arrhythmias, but their arrhythmogenic mechanisms are unclear. While some of the arrhythmogenic CaM mutations have been shown to impair CaM-dependent inhibition of intracellular Ca2+ release through the ryanodine receptor type 2 (RyR2), the impact of a majority of these mutations on RyR2 function is unknown. Here, we investigated the effect of 14 arrhythmogenic CaM mutations on the CaM-dependent RyR2 inhibition. We found that all the arrhythmogenic CaM mutations tested diminished CaM-dependent inhibition of RyR2-mediated Ca2+ release and increased store-overload induced Ca2+ release (SOICR) in HEK293 cells. Moreover, all the arrhythmogenic CaM mutations tested either failed to inhibit or even promoted RyR2-mediated Ca2+ release in permeabilized HEK293 cells with elevated cytosolic Ca2+ , which was markedly different from the inhibitory action of CaM wild-type. The CaM mutations also altered the Ca2+ -dependency of CaM binding to the RyR2 CaM-binding domain. These results demonstrate that diminished inhibition, and even facilitated activation, of RyR2-mediated Ca2+ release is a common defect of arrhythmogenic CaM mutations."xsd:string |
| http://purl.uniprot.org/citations/31230402 | http://purl.org/dc/terms/identifier | "doi:10.1111/febs.14969"xsd:string |
| http://purl.uniprot.org/citations/31230402 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/31230402 | http://purl.uniprot.org/core/author | "Guo W."xsd:string |
| http://purl.uniprot.org/citations/31230402 | http://purl.uniprot.org/core/author | "Overgaard M.T."xsd:string |
| http://purl.uniprot.org/citations/31230402 | http://purl.uniprot.org/core/author | "Sondergaard M.T."xsd:string |
| http://purl.uniprot.org/citations/31230402 | http://purl.uniprot.org/core/author | "Chen S.R.W."xsd:string |
| http://purl.uniprot.org/citations/31230402 | http://purl.uniprot.org/core/author | "Fill M."xsd:string |
| http://purl.uniprot.org/citations/31230402 | http://purl.uniprot.org/core/author | "Nani A."xsd:string |
| http://purl.uniprot.org/citations/31230402 | http://purl.uniprot.org/core/author | "Carvajal C."xsd:string |
| http://purl.uniprot.org/citations/31230402 | http://purl.uniprot.org/core/author | "Brohus M."xsd:string |
| http://purl.uniprot.org/citations/31230402 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31230402 | http://purl.uniprot.org/core/name | "FEBS J"xsd:string |
| http://purl.uniprot.org/citations/31230402 | http://purl.uniprot.org/core/pages | "4554-4578"xsd:string |
| http://purl.uniprot.org/citations/31230402 | http://purl.uniprot.org/core/title | "Diminished inhibition and facilitated activation of RyR2-mediated Ca2+ release is a common defect of arrhythmogenic calmodulin mutations."xsd:string |
| http://purl.uniprot.org/citations/31230402 | http://purl.uniprot.org/core/volume | "286"xsd:string |
| http://purl.uniprot.org/citations/31230402 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31230402 |
| http://purl.uniprot.org/citations/31230402 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31230402 |
| http://purl.uniprot.org/uniprot/#_B4DJ51-mappedCitation-31230402 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31230402 |
| http://purl.uniprot.org/uniprot/#_P0DP23-mappedCitation-31230402 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31230402 |
| http://purl.uniprot.org/uniprot/#_P0DP24-mappedCitation-31230402 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31230402 |
| http://purl.uniprot.org/uniprot/#_P0DP25-mappedCitation-31230402 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31230402 |
| http://purl.uniprot.org/uniprot/#_Q96HY3-mappedCitation-31230402 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31230402 |
| http://purl.uniprot.org/uniprot/B4DJ51 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31230402 |