| http://purl.uniprot.org/citations/31231034 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31231034 | http://www.w3.org/2000/01/rdf-schema#comment | "Tissue-resident macrophages require specific milieus for the maintenance of defining gene-expression programs. Expression of the transcription factor GATA6 is required for the homeostasis, function and localization of peritoneal cavity-resident macrophages. Gata6 expression is maintained in a non-cell autonomous manner and is elicited by the vitamin A metabolite, retinoic acid. Here, we found that the GATA6 transcriptional program is a common feature of macrophages residing in all visceral body cavities. Retinoic acid-dependent and -independent hallmark genes of GATA6+ macrophages were induced by mesothelial and fibroblastic stromal cells that express the transcription factor Wilms' Tumor 1 (WT1), which drives the expression of two rate-limiting enzymes in retinol metabolism. Depletion of Wt1+ stromal cells reduced the frequency of GATA6+ macrophages in the peritoneal, pleural and pericardial cavities. Thus, Wt1+ mesothelial and fibroblastic stromal cells constitute essential niche components supporting the tissue-specifying transcriptional landscape and homeostasis of cavity-resident macrophages."xsd:string |
| http://purl.uniprot.org/citations/31231034 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2019.05.010"xsd:string |
| http://purl.uniprot.org/citations/31231034 | http://purl.uniprot.org/core/author | "Li Q."xsd:string |
| http://purl.uniprot.org/citations/31231034 | http://purl.uniprot.org/core/author | "Sandoval W."xsd:string |
| http://purl.uniprot.org/citations/31231034 | http://purl.uniprot.org/core/author | "Harris C.A."xsd:string |
| http://purl.uniprot.org/citations/31231034 | http://purl.uniprot.org/core/author | "Kim K.W."xsd:string |
| http://purl.uniprot.org/citations/31231034 | http://purl.uniprot.org/core/author | "Cooper J.E."xsd:string |
| http://purl.uniprot.org/citations/31231034 | http://purl.uniprot.org/core/author | "Junttila M.R."xsd:string |
| http://purl.uniprot.org/citations/31231034 | http://purl.uniprot.org/core/author | "Turley S.J."xsd:string |
| http://purl.uniprot.org/citations/31231034 | http://purl.uniprot.org/core/author | "Randolph G.J."xsd:string |
| http://purl.uniprot.org/citations/31231034 | http://purl.uniprot.org/core/author | "Buechler M.B."xsd:string |
| http://purl.uniprot.org/citations/31231034 | http://purl.uniprot.org/core/author | "Williams J.W."xsd:string |
| http://purl.uniprot.org/citations/31231034 | http://purl.uniprot.org/core/author | "Little C.C."xsd:string |
| http://purl.uniprot.org/citations/31231034 | http://purl.uniprot.org/core/author | "Dominguez C.X."xsd:string |
| http://purl.uniprot.org/citations/31231034 | http://purl.uniprot.org/core/author | "Onufer E.J."xsd:string |
| http://purl.uniprot.org/citations/31231034 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31231034 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/31231034 | http://purl.uniprot.org/core/pages | "119-130.e5"xsd:string |
| http://purl.uniprot.org/citations/31231034 | http://purl.uniprot.org/core/title | "A Stromal Niche Defined by Expression of the Transcription Factor WT1 Mediates Programming and Homeostasis of Cavity-Resident Macrophages."xsd:string |
| http://purl.uniprot.org/citations/31231034 | http://purl.uniprot.org/core/volume | "51"xsd:string |
| http://purl.uniprot.org/citations/31231034 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31231034 |
| http://purl.uniprot.org/citations/31231034 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31231034 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGF4-mappedCitation-31231034 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31231034 |
| http://purl.uniprot.org/uniprot/#_A0A077S2U6-mappedCitation-31231034 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31231034 |