| http://purl.uniprot.org/citations/31233739 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31233739 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31233739 | http://www.w3.org/2000/01/rdf-schema#comment | "Paternal mitochondria are eliminated following fertilization by selective autophagy, but the mechanisms that restrict this process to sperm-derived organelles are not well understood. FUNDC1 (FUN14 domain containing 1) is a mammalian mitophagy receptor expressed on the mitochondrial outer membrane that contributes to mitochondrial quality control following hypoxic stress. Like FUNDC1, the C. elegans ortholog FNDC-1 is widely expressed in somatic tissues and mediates hypoxic mitophagy. Here, we report that FNDC-1 is strongly expressed in sperm but not oocytes and contributes to paternal mitochondria elimination. Paternal mitochondrial DNA is normally undetectable in wildtype larva, but can be detected in the cross-progeny of fndc-1 mutant males. Moreover, loss of fndc-1 retards the rate of paternal mitochondria degradation, but not that of membranous organelles, a nematode specific membrane compartment whose fusion is required for sperm motility. This is the first example of a ubiquitin-independent mitophagy receptor playing a role in the selective degradation of sperm mitochondria."xsd:string |
| http://purl.uniprot.org/citations/31233739 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ydbio.2019.06.016"xsd:string |
| http://purl.uniprot.org/citations/31233739 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ydbio.2019.06.016"xsd:string |
| http://purl.uniprot.org/citations/31233739 | http://purl.uniprot.org/core/author | "Lim Y."xsd:string |
| http://purl.uniprot.org/citations/31233739 | http://purl.uniprot.org/core/author | "Lim Y."xsd:string |
| http://purl.uniprot.org/citations/31233739 | http://purl.uniprot.org/core/author | "Nehrke K."xsd:string |
| http://purl.uniprot.org/citations/31233739 | http://purl.uniprot.org/core/author | "Nehrke K."xsd:string |
| http://purl.uniprot.org/citations/31233739 | http://purl.uniprot.org/core/author | "Brookes P.S."xsd:string |
| http://purl.uniprot.org/citations/31233739 | http://purl.uniprot.org/core/author | "Brookes P.S."xsd:string |
| http://purl.uniprot.org/citations/31233739 | http://purl.uniprot.org/core/author | "Galy V."xsd:string |
| http://purl.uniprot.org/citations/31233739 | http://purl.uniprot.org/core/author | "Galy V."xsd:string |
| http://purl.uniprot.org/citations/31233739 | http://purl.uniprot.org/core/author | "Molina P.A."xsd:string |
| http://purl.uniprot.org/citations/31233739 | http://purl.uniprot.org/core/author | "Molina P.A."xsd:string |
| http://purl.uniprot.org/citations/31233739 | http://purl.uniprot.org/core/author | "Rubio-Pena K."xsd:string |
| http://purl.uniprot.org/citations/31233739 | http://purl.uniprot.org/core/author | "Rubio-Pena K."xsd:string |
| http://purl.uniprot.org/citations/31233739 | http://purl.uniprot.org/core/author | "Sobraske P.J."xsd:string |
| http://purl.uniprot.org/citations/31233739 | http://purl.uniprot.org/core/author | "Sobraske P.J."xsd:string |
| http://purl.uniprot.org/citations/31233739 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31233739 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31233739 | http://purl.uniprot.org/core/name | "Dev. Biol."xsd:string |
| http://purl.uniprot.org/citations/31233739 | http://purl.uniprot.org/core/name | "Dev. Biol."xsd:string |
| http://purl.uniprot.org/citations/31233739 | http://purl.uniprot.org/core/pages | "15-20"xsd:string |
| http://purl.uniprot.org/citations/31233739 | http://purl.uniprot.org/core/pages | "15-20"xsd:string |