| http://purl.uniprot.org/citations/31235567 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31235567 | http://www.w3.org/2000/01/rdf-schema#comment | "Wnt/Wingless (Wg) signaling controls many aspects of animal development and is deregulated in different human cancers. The transcription factor dTcf/Pangolin (Pan) is the final effector of the Wg pathway in Drosophila and has a dual role in regulating the expression of Wg target genes. In the presence of Wg, dTcf/Pan interacts with β-catenin/Armadillo (Arm) and induces the transcription of Wg targets. In absence of Wg, dTcf/Pan partners with the transcriptional corepressor TLE/Groucho (Gro) and inhibits gene expression. Here, we use the wing imaginal disk of Drosophila as a model to examine the functions that dTcf/Pan plays in a proliferating epithelium. We report a function of dTcf/Pan in growth control and tumorigenesis. Our results show that dTcf/Pan can limit tissue growth in normal development and suppresses tumorigenesis in the context of oncogene up-regulation. We identify the conserved transcription factors Sox box protein 15 (Sox15) and Ftz transcription factor 1 (Ftz-f1) as genes controlled by dTcf/Pan involved in tumor development. In conclusion, this study reports a role for dTcf/Pan as a repressor of normal and oncogenic growth and identifies the genes inducing tumorigenesis downstream of dTcf/Pan."xsd:string |
| http://purl.uniprot.org/citations/31235567 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1816981116"xsd:string |
| http://purl.uniprot.org/citations/31235567 | http://purl.uniprot.org/core/author | "Song S."xsd:string |
| http://purl.uniprot.org/citations/31235567 | http://purl.uniprot.org/core/author | "Cohen S.M."xsd:string |
| http://purl.uniprot.org/citations/31235567 | http://purl.uniprot.org/core/author | "Herranz H."xsd:string |
| http://purl.uniprot.org/citations/31235567 | http://purl.uniprot.org/core/author | "Freitas F.C.P."xsd:string |
| http://purl.uniprot.org/citations/31235567 | http://purl.uniprot.org/core/author | "Andrejeva D."xsd:string |
| http://purl.uniprot.org/citations/31235567 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31235567 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/31235567 | http://purl.uniprot.org/core/pages | "14055-14064"xsd:string |
| http://purl.uniprot.org/citations/31235567 | http://purl.uniprot.org/core/title | "dTcf/Pangolin suppresses growth and tumor formation in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/31235567 | http://purl.uniprot.org/core/volume | "116"xsd:string |
| http://purl.uniprot.org/citations/31235567 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31235567 |
| http://purl.uniprot.org/citations/31235567 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31235567 |
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