| http://purl.uniprot.org/citations/31243295 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31243295 | http://www.w3.org/2000/01/rdf-schema#comment | "Reactive oxygen species (ROS) contribute to myocardial death during ischemia-reperfusion (I/R) injury, but detailed knowledge of molecular pathways connecting ROS to cardiac injury is lacking. Activation of the Ca2+/calmodulin-dependent protein kinase II (CaMKIIδ) is implicated in myocardial death, and CaMKII can be activated by ROS (ox-CaMKII) through oxidation of regulatory domain methionines (Met281/282). We examined I/R injury in mice where CaMKIIδ was made resistant to ROS activation by knock-in replacement of regulatory domain methionines with valines (MMVV). We found reduced myocardial death, and improved left ventricular function 24 hours after I/R injury in MMVV in vivo and in vitro compared to WT controls. Loss of ATP sensitive K+ channel (KATP) current contributes to I/R injury, and CaMKII promotes sequestration of KATP from myocardial cell membranes. KATP current density was significantly reduced by H2O2 in WT ventricular myocytes, but not in MMVV, showing ox-CaMKII decreases KATP availability. Taken together, these findings support a view that ox-CaMKII and KATP are components of a signaling axis promoting I/R injury by ROS."xsd:string |
| http://purl.uniprot.org/citations/31243295 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-019-45743-6"xsd:string |
| http://purl.uniprot.org/citations/31243295 | http://purl.uniprot.org/core/author | "Wu Y."xsd:string |
| http://purl.uniprot.org/citations/31243295 | http://purl.uniprot.org/core/author | "Wang Q."xsd:string |
| http://purl.uniprot.org/citations/31243295 | http://purl.uniprot.org/core/author | "Feng N."xsd:string |
| http://purl.uniprot.org/citations/31243295 | http://purl.uniprot.org/core/author | "Anderson M.E."xsd:string |
| http://purl.uniprot.org/citations/31243295 | http://purl.uniprot.org/core/author | "Granger J.M."xsd:string |
| http://purl.uniprot.org/citations/31243295 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31243295 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/31243295 | http://purl.uniprot.org/core/pages | "9291"xsd:string |
| http://purl.uniprot.org/citations/31243295 | http://purl.uniprot.org/core/title | "Myocardial death and dysfunction after ischemia-reperfusion injury require CaMKIIdelta oxidation."xsd:string |
| http://purl.uniprot.org/citations/31243295 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/31243295 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31243295 |
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| http://purl.uniprot.org/uniprot/#_E9QAJ4-mappedCitation-31243295 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31243295 |
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