| http://purl.uniprot.org/citations/31248780 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31248780 | http://www.w3.org/2000/01/rdf-schema#comment | "Genetic variation influences how the genome is interpreted in individuals and in mouse strains used to model immune responses. We developed approaches to utilize next-generation sequencing datasets to identify sequence variation in genes and enhancer elements in congenic and backcross mouse models. We defined genetic variation in the widely used B6-CD45.2 and B6.SJL-CD45.1 congenic model, identifying substantial differences in SJL genetic content retained in B6.SJL-CD45.1 strains on the basis of the vendor source of the mice. Genes encoding PD-1, CD62L, Bcl-2, cathepsin E, and Cxcr4 were within SJL genetic content in at least one vendor source of B6.SJL-CD45.1 mice. SJL genetic content affected enhancer elements, gene regulation, protein expression, and amino acid content in CD4+ T helper 1 cells, and mice infected with influenza showed reduced expression of Cxcr4 on B6.SJL-CD45.1 T follicular helper cells. These findings provide information on experimental variables and aid in creating approaches that account for genetic variables."xsd:string |
| http://purl.uniprot.org/citations/31248780 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2019.05.006"xsd:string |
| http://purl.uniprot.org/citations/31248780 | http://purl.uniprot.org/core/author | "Cheng W."xsd:string |
| http://purl.uniprot.org/citations/31248780 | http://purl.uniprot.org/core/author | "Randall T.D."xsd:string |
| http://purl.uniprot.org/citations/31248780 | http://purl.uniprot.org/core/author | "Weinmann A.S."xsd:string |
| http://purl.uniprot.org/citations/31248780 | http://purl.uniprot.org/core/author | "Meza-Perez S."xsd:string |
| http://purl.uniprot.org/citations/31248780 | http://purl.uniprot.org/core/author | "Chisolm D.A."xsd:string |
| http://purl.uniprot.org/citations/31248780 | http://purl.uniprot.org/core/author | "Colburn S.A."xsd:string |
| http://purl.uniprot.org/citations/31248780 | http://purl.uniprot.org/core/author | "Silva-Sanchez A."xsd:string |
| http://purl.uniprot.org/citations/31248780 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31248780 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/31248780 | http://purl.uniprot.org/core/pages | "155-168.e5"xsd:string |
| http://purl.uniprot.org/citations/31248780 | http://purl.uniprot.org/core/title | "Defining Genetic Variation in Widely Used Congenic and Backcrossed Mouse Models Reveals Varied Regulation of Genes Important for Immune Responses."xsd:string |
| http://purl.uniprot.org/citations/31248780 | http://purl.uniprot.org/core/volume | "51"xsd:string |
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