| http://purl.uniprot.org/citations/31251782 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31251782 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31251782 | http://www.w3.org/2000/01/rdf-schema#comment | "Inflammasomes are cytosolic multi-protein complexes that detect infection or cellular damage and activate the Caspase-1 (CASP1) protease. The NAIP5/NLRC4 inflammasome detects bacterial flagellin and is essential for resistance to the flagellated intracellular bacterium Legionella pneumophila. The effectors required downstream of NAIP5/NLRC4 to restrict bacterial replication remain unclear. Upon NAIP5/NLRC4 activation, CASP1 cleaves and activates the pore-forming protein Gasdermin-D (GSDMD) and the effector caspase-7 (CASP7). However, Casp1-/-(and Casp1/11-/-) mice are only partially susceptible to L. pneumophila and do not phenocopy Nlrc4-/-mice, because NAIP5/NLRC4 also activates CASP8 for restriction of L. pneumophila infection. Here we show that CASP8 promotes the activation of CASP7 and that Casp7/1/11-/- and Casp8/1/11-/-mice recapitulate the full susceptibility of Nlrc4-/- mice. Gsdmd-/-mice exhibit only mild susceptibility to L. pneumophila, but Gsdmd-/-Casp7-/-mice are as susceptible as the Nlrc4-/-mice. These results demonstrate that GSDMD and CASP7 are the key substrates downstream of NAIP5/NLRC4/CASP1/8 required for resistance to L. pneumophila."xsd:string |
| http://purl.uniprot.org/citations/31251782 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.ppat.1007886"xsd:string |
| http://purl.uniprot.org/citations/31251782 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.ppat.1007886"xsd:string |
| http://purl.uniprot.org/citations/31251782 | http://purl.uniprot.org/core/author | "Vance R.E."xsd:string |
| http://purl.uniprot.org/citations/31251782 | http://purl.uniprot.org/core/author | "Vance R.E."xsd:string |
| http://purl.uniprot.org/citations/31251782 | http://purl.uniprot.org/core/author | "Fontana M.F."xsd:string |
| http://purl.uniprot.org/citations/31251782 | http://purl.uniprot.org/core/author | "Fontana M.F."xsd:string |
| http://purl.uniprot.org/citations/31251782 | http://purl.uniprot.org/core/author | "Ansaldo E."xsd:string |
| http://purl.uniprot.org/citations/31251782 | http://purl.uniprot.org/core/author | "Ansaldo E."xsd:string |
| http://purl.uniprot.org/citations/31251782 | http://purl.uniprot.org/core/author | "Zamboni D.S."xsd:string |
| http://purl.uniprot.org/citations/31251782 | http://purl.uniprot.org/core/author | "Zamboni D.S."xsd:string |
| http://purl.uniprot.org/citations/31251782 | http://purl.uniprot.org/core/author | "Goncalves A.V."xsd:string |
| http://purl.uniprot.org/citations/31251782 | http://purl.uniprot.org/core/author | "Goncalves A.V."xsd:string |
| http://purl.uniprot.org/citations/31251782 | http://purl.uniprot.org/core/author | "Margolis S.R."xsd:string |
| http://purl.uniprot.org/citations/31251782 | http://purl.uniprot.org/core/author | "Margolis S.R."xsd:string |
| http://purl.uniprot.org/citations/31251782 | http://purl.uniprot.org/core/author | "Mascarenhas D.P.A."xsd:string |
| http://purl.uniprot.org/citations/31251782 | http://purl.uniprot.org/core/author | "Mascarenhas D.P.A."xsd:string |
| http://purl.uniprot.org/citations/31251782 | http://purl.uniprot.org/core/author | "Nichols R.D."xsd:string |
| http://purl.uniprot.org/citations/31251782 | http://purl.uniprot.org/core/author | "Nichols R.D."xsd:string |
| http://purl.uniprot.org/citations/31251782 | http://purl.uniprot.org/core/author | "Quirino G.F.S."xsd:string |
| http://purl.uniprot.org/citations/31251782 | http://purl.uniprot.org/core/author | "Quirino G.F.S."xsd:string |
| http://purl.uniprot.org/citations/31251782 | http://purl.uniprot.org/core/author | "Rauch I."xsd:string |
| http://purl.uniprot.org/citations/31251782 | http://purl.uniprot.org/core/author | "Rauch I."xsd:string |