| http://purl.uniprot.org/citations/31251974 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31251974 | http://www.w3.org/2000/01/rdf-schema#comment | "Monoacylglycerol lipase (MAGL) is the main enzyme implicated in the degradation of the most abundant endocannabinoid in the brain, 2-arachidonoylglycerol (2-AG), producing arachidonic acid (AA) and glycerol. MAGL pharmacological inhibition with JZL184 or genetic deletion results in an exacerbated 2-AG signaling and reduced synthesis of prostaglandins (PGs), due to the reduced AA precursor levels. We found that acute JZL184 administration, previously described to exert anti-inflammatory effects, and MAGL knockout (KO) mice display cerebellar, but not hippocampal, microglial reactivity, accompanied with increased expression of the mRNA levels of neuroinflammatory markers, such as cyclooxygenase-2 (COX-2). Notably, this neuroinflammatory phenotype correlated with relevant motor coordination impairment in the beam-walking and the footprint tests. Treatment with the COX-2 inhibitor NS398 during 5 days prevented the deficits in cerebellar function and the cerebellar microglia reactivity in MAGL KO, without affecting hippocampal reactivity. Altogether, this study reveals the brain region-specific response to MAGL inhibition, with an important role of COX-2 in the cerebellar deficits associated, which should be taken into account for the use of MAGL inhibitors as anti-inflammatory drugs."xsd:string |
| http://purl.uniprot.org/citations/31251974 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbi.2019.06.036"xsd:string |
| http://purl.uniprot.org/citations/31251974 | http://purl.uniprot.org/core/author | "Kato A."xsd:string |
| http://purl.uniprot.org/citations/31251974 | http://purl.uniprot.org/core/author | "Valjent E."xsd:string |
| http://purl.uniprot.org/citations/31251974 | http://purl.uniprot.org/core/author | "Kano M."xsd:string |
| http://purl.uniprot.org/citations/31251974 | http://purl.uniprot.org/core/author | "Sakimura K."xsd:string |
| http://purl.uniprot.org/citations/31251974 | http://purl.uniprot.org/core/author | "Maldonado R."xsd:string |
| http://purl.uniprot.org/citations/31251974 | http://purl.uniprot.org/core/author | "Ozaita A."xsd:string |
| http://purl.uniprot.org/citations/31251974 | http://purl.uniprot.org/core/author | "Pastor A."xsd:string |
| http://purl.uniprot.org/citations/31251974 | http://purl.uniprot.org/core/author | "de la Torre R."xsd:string |
| http://purl.uniprot.org/citations/31251974 | http://purl.uniprot.org/core/author | "Cutando L."xsd:string |
| http://purl.uniprot.org/citations/31251974 | http://purl.uniprot.org/core/author | "Martinez-Torres S."xsd:string |
| http://purl.uniprot.org/citations/31251974 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31251974 | http://purl.uniprot.org/core/name | "Brain Behav Immun"xsd:string |
| http://purl.uniprot.org/citations/31251974 | http://purl.uniprot.org/core/pages | "399-409"xsd:string |
| http://purl.uniprot.org/citations/31251974 | http://purl.uniprot.org/core/title | "Monoacylglycerol lipase blockade impairs fine motor coordination and triggers cerebellar neuroinflammation through cyclooxygenase-2."xsd:string |
| http://purl.uniprot.org/citations/31251974 | http://purl.uniprot.org/core/volume | "81"xsd:string |
| http://purl.uniprot.org/citations/31251974 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31251974 |
| http://purl.uniprot.org/citations/31251974 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31251974 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SUZ2-mappedCitation-31251974 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31251974 |
| http://purl.uniprot.org/uniprot/#_D3YYS6-mappedCitation-31251974 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31251974 |
| http://purl.uniprot.org/uniprot/#_E9Q3B9-mappedCitation-31251974 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31251974 |
| http://purl.uniprot.org/uniprot/#_Q3UFN1-mappedCitation-31251974 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31251974 |
| http://purl.uniprot.org/uniprot/#_Q3UFX6-mappedCitation-31251974 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31251974 |