| http://purl.uniprot.org/citations/31255281 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31255281 | http://www.w3.org/2000/01/rdf-schema#comment | "The GAIT (gamma-interferon-activated inhibitor of translation) complex or miR-297-RISC (RNA-induced silencing complex), together with hnRNP L or hnRNP L-bearing complex, operates an RNA switch in myeloid cells that regulates stress-dependent expression of vascular endothelial growth factor-A (VEGFA). Here, we have shown that hnRNP L directs multiple hypoxia-inducible RNA switches simultaneously and regulates expression of these oncogenic genes in addition to VEGFA. Bioinformatic and polysome profiling-microarray screens have identified DNM1L (Dynamin 1-like) and PHF21A (PHD finger protein 21A) mRNAs as regulated at the translational level by GAIT-dependent, hnRNP L-directed RNA switches. We have also uncovered CDK6 (Cyclin dependent kinase 6), MKLN1 (Muskelin 1) and EIF5 (Eukaryotic initiation factor 5) as novel miR-297-dependent, hnRNP L-directed RNA switch transcripts. Src Kinase is required for the phosphorylation of hnRNP L and activation of the RNA switch pathway. Knockdown of hnRNP L sensitizes the human U937 monocytic cells under hypoxia stress but not in normoxia via inducing cell apoptosis partially due to the reduced translation of hnRNP L target mRNAs. Collectively, our findings suggest that commonly controlled genes by the hnRNP L-directed RNA switches form a translational regulon that promotes hypoxia resistance and cell survival."xsd:string |
| http://purl.uniprot.org/citations/31255281 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2019.06.106"xsd:string |
| http://purl.uniprot.org/citations/31255281 | http://purl.uniprot.org/core/author | "Wu J."xsd:string |
| http://purl.uniprot.org/citations/31255281 | http://purl.uniprot.org/core/author | "Yao P."xsd:string |
| http://purl.uniprot.org/citations/31255281 | http://purl.uniprot.org/core/author | "Potdar A."xsd:string |
| http://purl.uniprot.org/citations/31255281 | http://purl.uniprot.org/core/author | "Venkata Subbaiah K.C."xsd:string |
| http://purl.uniprot.org/citations/31255281 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31255281 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/31255281 | http://purl.uniprot.org/core/pages | "753-759"xsd:string |
| http://purl.uniprot.org/citations/31255281 | http://purl.uniprot.org/core/title | "hnRNP L-mediated RNA switches function as a hypoxia-induced translational regulon."xsd:string |
| http://purl.uniprot.org/citations/31255281 | http://purl.uniprot.org/core/volume | "516"xsd:string |
| http://purl.uniprot.org/citations/31255281 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31255281 |
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