| http://purl.uniprot.org/citations/31265880 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31265880 | http://www.w3.org/2000/01/rdf-schema#comment | "Ets-1 is one of the crucial member of transcription factor family which share a unique DNA binding domain. It is predominantly expressed in various tumor subtypes and has shown its association in the regulation of various important genes which include ECM-degrading proteases. Our study aimed to understand the mechanism(s) in the pathogenesis of breast carcinogenesis by Ets-1 transcription factor and its downstream target gene MMP-9. Role of Ets-1 in MCF-7 and MDA-MB-231 breast cancer cells was studied by RNA-interference in combination with pull down and ChIP assays to identify the regulation of MMP-9 in these cell lines. Our results showed that transfection of Ets-1 siRNA in breast cancer cell lines resulted in downregulation of Ets-1 and MMP-9. Ets-1 knock down also showed reduced cell invasion and altered expression of EMT markers. Moreover, we could also predict that MMP-9 gene promoter harbors a binding site for Ets-1 transcription factor may be responsible in direct transactivation of Ets-1 along with EMT markers. Phenotypic changes and molecular alterations that may result in increased aggressiveness/invasiveness and metastatic nature of cancerous cells may lead to changes in EMT markers. Therefore, these findings may suggest a plausible role of Ets-1 dependent regulation of MMP-9 gene and may have a significant impact on breast carcinogenesis."xsd:string |
| http://purl.uniprot.org/citations/31265880 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.gene.2019.143952"xsd:string |
| http://purl.uniprot.org/citations/31265880 | http://purl.uniprot.org/core/author | "Singh A."xsd:string |
| http://purl.uniprot.org/citations/31265880 | http://purl.uniprot.org/core/author | "Kumar R."xsd:string |
| http://purl.uniprot.org/citations/31265880 | http://purl.uniprot.org/core/author | "Khan A."xsd:string |
| http://purl.uniprot.org/citations/31265880 | http://purl.uniprot.org/core/author | "Tripathi R."xsd:string |
| http://purl.uniprot.org/citations/31265880 | http://purl.uniprot.org/core/author | "Hussain S."xsd:string |
| http://purl.uniprot.org/citations/31265880 | http://purl.uniprot.org/core/author | "Mehrotra R."xsd:string |
| http://purl.uniprot.org/citations/31265880 | http://purl.uniprot.org/core/author | "Nazir S.U."xsd:string |
| http://purl.uniprot.org/citations/31265880 | http://purl.uniprot.org/core/author | "Tanwar P."xsd:string |
| http://purl.uniprot.org/citations/31265880 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31265880 | http://purl.uniprot.org/core/name | "Gene"xsd:string |
| http://purl.uniprot.org/citations/31265880 | http://purl.uniprot.org/core/pages | "143952"xsd:string |
| http://purl.uniprot.org/citations/31265880 | http://purl.uniprot.org/core/title | "Breast cancer invasion and progression by MMP-9 through Ets-1 transcription factor."xsd:string |
| http://purl.uniprot.org/citations/31265880 | http://purl.uniprot.org/core/volume | "711"xsd:string |
| http://purl.uniprot.org/citations/31265880 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31265880 |
| http://purl.uniprot.org/citations/31265880 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31265880 |
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| http://purl.uniprot.org/uniprot/#_F2YBS6-mappedCitation-31265880 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31265880 |