| http://purl.uniprot.org/citations/31266264 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31266264 | http://www.w3.org/2000/01/rdf-schema#comment | "Chronic inflammation and angiogenesis are associated with colonic carcinogenesis. Enteric glia-derived S100B protein has been proposed as an "ideal bridge", linking colonic inflammation and cancer, given its dual ability to up-regulate nuclear factor-kappaB (NF-κB) transcription via receptor for advanced glycation end products (RAGE) signaling and to sequestrate wild type pro-apoptotic wild type (wt)p53. However, its pro-angiogenic effects on cancer cells are still uninvestigated. To this aim, we evaluated the effect of exogenous S100B (0.05-5 µM) protein alone or in the presence of S100B blocking monoclonal antibody (mAb) (1:105-1:104 v/v diluted) on (1) cultured Caco-2 cells proliferation, migration and invasiveness in vitro, respectively by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT)-formazan, wound healing and matrigel invasion assays and (2) its effect on the release of pro-angiogenic factors, such as vascular endothelial growth factor (VEGF) by ELISA and immunofluorescence analyses. The effect of S100B alone or in the presence of S100BmAb was then investigated on RAGE/pAkt/mammalian target of rapamycin (mTOR) signaling pathway by immunoblot analysis. Our results showed that S100B markedly increases proliferation and invasiveness of Caco-2 cells, through the release of pro-angiogenic VEGF and NO paralleled to a significant decrease of wtp53 expression mediated by RAGE-p38 mitogen-activated protein kinase (MAPK)/pAkt-mTOR and hypoxia-inducible factor 1-alpha (HIF1α) pathways. Such effects were counteracted by S100BmAb, indicating that S100B targeting is a potential approach to inhibit colon carcinoma proliferation and angiogenesis."xsd:string |
| http://purl.uniprot.org/citations/31266264 | http://purl.org/dc/terms/identifier | "doi:10.3390/ijms20133240"xsd:string |
| http://purl.uniprot.org/citations/31266264 | http://purl.uniprot.org/core/author | "Esposito G."xsd:string |
| http://purl.uniprot.org/citations/31266264 | http://purl.uniprot.org/core/author | "Pesce M."xsd:string |
| http://purl.uniprot.org/citations/31266264 | http://purl.uniprot.org/core/author | "Sarnelli G."xsd:string |
| http://purl.uniprot.org/citations/31266264 | http://purl.uniprot.org/core/author | "Annunziata G."xsd:string |
| http://purl.uniprot.org/citations/31266264 | http://purl.uniprot.org/core/author | "Capuano R."xsd:string |
| http://purl.uniprot.org/citations/31266264 | http://purl.uniprot.org/core/author | "Seguella L."xsd:string |
| http://purl.uniprot.org/citations/31266264 | http://purl.uniprot.org/core/author | "Aurino L."xsd:string |
| http://purl.uniprot.org/citations/31266264 | http://purl.uniprot.org/core/author | "Pesce M.'"xsd:string |
| http://purl.uniprot.org/citations/31266264 | http://purl.uniprot.org/core/author | "de Conno B."xsd:string |
| http://purl.uniprot.org/citations/31266264 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31266264 | http://purl.uniprot.org/core/name | "Int J Mol Sci"xsd:string |
| http://purl.uniprot.org/citations/31266264 | http://purl.uniprot.org/core/pages | "E3240"xsd:string |
| http://purl.uniprot.org/citations/31266264 | http://purl.uniprot.org/core/title | "S100B Protein Stimulates Proliferation and Angiogenic Mediators Release through RAGE/pAkt/mTOR Pathway in Human Colon Adenocarcinoma Caco-2 Cells."xsd:string |
| http://purl.uniprot.org/citations/31266264 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/31266264 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31266264 |
| http://purl.uniprot.org/citations/31266264 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31266264 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4C5-mappedCitation-31266264 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31266264 |
| http://purl.uniprot.org/uniprot/#_A8MRB1-mappedCitation-31266264 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31266264 |
| http://purl.uniprot.org/uniprot/#_P04271-mappedCitation-31266264 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31266264 |
| http://purl.uniprot.org/uniprot/A8MRB1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31266264 |
| http://purl.uniprot.org/uniprot/P04271 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31266264 |
| http://purl.uniprot.org/uniprot/A0A0S2Z4C5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31266264 |