| http://purl.uniprot.org/citations/31268774 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31268774 | http://www.w3.org/2000/01/rdf-schema#comment | "Recent reports suggest that the Hippo signaling pathway influences ovarian follicle development; however, its exact roles remain unknown. Here, we examined the ovarian functions of the Hippo kinases large tumor suppressors (LATS)1 and 2, which serve to inactivate the transcriptional coactivators Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ). Inactivation of Lats1/2 in murine granulosa cells either in vitro or in vivo resulted in a loss of granulosa cell morphology, function, and gene expression. Mutant cells further underwent changes in structure and gene expression suggestive of epithelial-to-mesenchymal transition and transdifferentiation into multiple lineages. In vivo, granulosa cell-specific loss of Lats1/2 caused the ovarian parenchyma to be mostly replaced by bone tissue and seminiferous tubule-like structures. Transdifferentiation into Sertoli-like cells and osteoblasts was attributed in part to the increased recruitment of YAP and TAZ to the promoters of sex-determining region Y box 9 and bone γ-carboxyglutamate protein, key mediators of male sex determination and osteogenesis, respectively. Together, these results demonstrate for the first time a critical role for Lats1/2 in the maintenance of the granulosa cell genetic program and further highlight the remarkable plasticity of granulosa cells.-Tsoi, M., Morin, M., Rico, C., Johnson, R. L., Paquet, M., Gévry, N., Boerboom, D. Lats1 and Lats2 are required for ovarian granulosa cell fate maintenance."xsd:string |
| http://purl.uniprot.org/citations/31268774 | http://purl.org/dc/terms/identifier | "doi:10.1096/fj.201900609r"xsd:string |
| http://purl.uniprot.org/citations/31268774 | http://purl.uniprot.org/core/author | "Boerboom D."xsd:string |
| http://purl.uniprot.org/citations/31268774 | http://purl.uniprot.org/core/author | "Johnson R.L."xsd:string |
| http://purl.uniprot.org/citations/31268774 | http://purl.uniprot.org/core/author | "Morin M."xsd:string |
| http://purl.uniprot.org/citations/31268774 | http://purl.uniprot.org/core/author | "Rico C."xsd:string |
| http://purl.uniprot.org/citations/31268774 | http://purl.uniprot.org/core/author | "Tsoi M."xsd:string |
| http://purl.uniprot.org/citations/31268774 | http://purl.uniprot.org/core/author | "Gevry N."xsd:string |
| http://purl.uniprot.org/citations/31268774 | http://purl.uniprot.org/core/author | "Paquet M."xsd:string |
| http://purl.uniprot.org/citations/31268774 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31268774 | http://purl.uniprot.org/core/name | "FASEB J"xsd:string |
| http://purl.uniprot.org/citations/31268774 | http://purl.uniprot.org/core/pages | "10819-10832"xsd:string |
| http://purl.uniprot.org/citations/31268774 | http://purl.uniprot.org/core/title | "Lats1 and Lats2 are required for ovarian granulosa cell fate maintenance."xsd:string |
| http://purl.uniprot.org/citations/31268774 | http://purl.uniprot.org/core/volume | "33"xsd:string |
| http://purl.uniprot.org/citations/31268774 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31268774 |
| http://purl.uniprot.org/citations/31268774 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31268774 |
| http://purl.uniprot.org/uniprot/#_G3UWQ0-mappedCitation-31268774 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31268774 |
| http://purl.uniprot.org/uniprot/#_G3UXX1-mappedCitation-31268774 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31268774 |
| http://purl.uniprot.org/uniprot/#_G3UY78-mappedCitation-31268774 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31268774 |
| http://purl.uniprot.org/uniprot/#_G3UYM3-mappedCitation-31268774 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31268774 |
| http://purl.uniprot.org/uniprot/#_G3UZ29-mappedCitation-31268774 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31268774 |
| http://purl.uniprot.org/uniprot/#_Q8BYR2-mappedCitation-31268774 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31268774 |
| http://purl.uniprot.org/uniprot/#_Q7TSJ6-mappedCitation-31268774 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31268774 |
| http://purl.uniprot.org/uniprot/#_Q8VHE1-mappedCitation-31268774 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31268774 |