| http://purl.uniprot.org/citations/31272808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31272808 | http://www.w3.org/2000/01/rdf-schema#comment | "Interactions with the microbiota influence many aspects of immunity, including immune cell development, differentiation, and function. Here, we examined the impact of the microbiota on CD8+ T cell memory. Antigen-activated CD8+ T cells transferred into germ-free mice failed to transition into long-lived memory cells and had transcriptional impairments in core genes associated with oxidative metabolism. The microbiota-derived short-chain fatty acid (SCFA) butyrate promoted cellular metabolism, enhanced memory potential of activated CD8+ T cells, and SCFAs were required for optimal recall responses upon antigen re-encounter. Mechanistic experiments revealed that butyrate uncoupled the tricarboxylic acid cycle from glycolytic input in CD8+ T cells, which allowed preferential fueling of oxidative phosphorylation through sustained glutamine utilization and fatty acid catabolism. Our findings reveal a role for the microbiota in promoting CD8+ T cell long-term survival as memory cells and suggest that microbial metabolites guide the metabolic rewiring of activated CD8+ T cells to enable this transition."xsd:string |
| http://purl.uniprot.org/citations/31272808 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2019.06.002"xsd:string |
| http://purl.uniprot.org/citations/31272808 | http://purl.uniprot.org/core/author | "Lew A.M."xsd:string |
| http://purl.uniprot.org/citations/31272808 | http://purl.uniprot.org/core/author | "McConville M.J."xsd:string |
| http://purl.uniprot.org/citations/31272808 | http://purl.uniprot.org/core/author | "Turner S.J."xsd:string |
| http://purl.uniprot.org/citations/31272808 | http://purl.uniprot.org/core/author | "Mackay F."xsd:string |
| http://purl.uniprot.org/citations/31272808 | http://purl.uniprot.org/core/author | "Tull D."xsd:string |
| http://purl.uniprot.org/citations/31272808 | http://purl.uniprot.org/core/author | "Jonsson J."xsd:string |
| http://purl.uniprot.org/citations/31272808 | http://purl.uniprot.org/core/author | "Bedoui S."xsd:string |
| http://purl.uniprot.org/citations/31272808 | http://purl.uniprot.org/core/author | "Whitney P.G."xsd:string |
| http://purl.uniprot.org/citations/31272808 | http://purl.uniprot.org/core/author | "Kallies A."xsd:string |
| http://purl.uniprot.org/citations/31272808 | http://purl.uniprot.org/core/author | "Kupz A."xsd:string |
| http://purl.uniprot.org/citations/31272808 | http://purl.uniprot.org/core/author | "Fernandez-Ruiz D."xsd:string |
| http://purl.uniprot.org/citations/31272808 | http://purl.uniprot.org/core/author | "Gebhardt T."xsd:string |
| http://purl.uniprot.org/citations/31272808 | http://purl.uniprot.org/core/author | "Kastenmuller W."xsd:string |
| http://purl.uniprot.org/citations/31272808 | http://purl.uniprot.org/core/author | "Bachem A."xsd:string |
| http://purl.uniprot.org/citations/31272808 | http://purl.uniprot.org/core/author | "Binger K.J."xsd:string |
| http://purl.uniprot.org/citations/31272808 | http://purl.uniprot.org/core/author | "Parish I.A."xsd:string |
| http://purl.uniprot.org/citations/31272808 | http://purl.uniprot.org/core/author | "Hochheiser K."xsd:string |
| http://purl.uniprot.org/citations/31272808 | http://purl.uniprot.org/core/author | "Perdomo C."xsd:string |
| http://purl.uniprot.org/citations/31272808 | http://purl.uniprot.org/core/author | "Figgett W."xsd:string |
| http://purl.uniprot.org/citations/31272808 | http://purl.uniprot.org/core/author | "Makhlouf C."xsd:string |
| http://purl.uniprot.org/citations/31272808 | http://purl.uniprot.org/core/author | "Russ B.E."xsd:string |
| http://purl.uniprot.org/citations/31272808 | http://purl.uniprot.org/core/author | "Gressier E."xsd:string |