| http://purl.uniprot.org/citations/31278385 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31278385 | http://www.w3.org/2000/01/rdf-schema#comment | "The high-conductance intracellular calcium (Ca2+) channel RyR2 is essential for the coupling of excitation and contraction in cardiac muscle. Among various modulators, calmodulin (CaM) regulates RyR2 in a Ca2+-dependent manner. Here we reveal the regulatory mechanism by which porcine RyR2 is modulated by human CaM through the structural determination of RyR2 under eight conditions. Apo-CaM and Ca2+-CaM bind to distinct but overlapping sites in an elongated cleft formed by the handle, helical and central domains. The shift in CaM-binding sites on RyR2 is controlled by Ca2+ binding to CaM, rather than to RyR2. Ca2+-CaM induces rotations and intradomain shifts of individual central domains, resulting in pore closure of the PCB95 and Ca2+-activated channel. By contrast, the pore of the ATP, caffeine and Ca2+-activated channel remains open in the presence of Ca2+-CaM, which suggests that Ca2+-CaM is one of the many competing modulators of RyR2 gating."xsd:string |
| http://purl.uniprot.org/citations/31278385 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41586-019-1377-y"xsd:string |
| http://purl.uniprot.org/citations/31278385 | http://purl.uniprot.org/core/author | "Huang G."xsd:string |
| http://purl.uniprot.org/citations/31278385 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/31278385 | http://purl.uniprot.org/core/author | "Wang R."xsd:string |
| http://purl.uniprot.org/citations/31278385 | http://purl.uniprot.org/core/author | "Wei J."xsd:string |
| http://purl.uniprot.org/citations/31278385 | http://purl.uniprot.org/core/author | "Zhou G."xsd:string |
| http://purl.uniprot.org/citations/31278385 | http://purl.uniprot.org/core/author | "Chi X."xsd:string |
| http://purl.uniprot.org/citations/31278385 | http://purl.uniprot.org/core/author | "Lei J."xsd:string |
| http://purl.uniprot.org/citations/31278385 | http://purl.uniprot.org/core/author | "Yan N."xsd:string |
| http://purl.uniprot.org/citations/31278385 | http://purl.uniprot.org/core/author | "Gong D."xsd:string |
| http://purl.uniprot.org/citations/31278385 | http://purl.uniprot.org/core/author | "Chen S.R.W."xsd:string |
| http://purl.uniprot.org/citations/31278385 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31278385 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/31278385 | http://purl.uniprot.org/core/pages | "347-351"xsd:string |
| http://purl.uniprot.org/citations/31278385 | http://purl.uniprot.org/core/title | "Modulation of cardiac ryanodine receptor 2 by calmodulin."xsd:string |
| http://purl.uniprot.org/citations/31278385 | http://purl.uniprot.org/core/volume | "572"xsd:string |
| http://purl.uniprot.org/citations/31278385 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31278385 |
| http://purl.uniprot.org/citations/31278385 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31278385 |
| http://purl.uniprot.org/uniprot/#_B4DJ51-mappedCitation-31278385 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31278385 |
| http://purl.uniprot.org/uniprot/#_P0DP23-mappedCitation-31278385 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31278385 |
| http://purl.uniprot.org/uniprot/#_P0DP24-mappedCitation-31278385 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31278385 |
| http://purl.uniprot.org/uniprot/#_P0DP25-mappedCitation-31278385 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31278385 |
| http://purl.uniprot.org/uniprot/#_P68106-mappedCitation-31278385 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31278385 |