| http://purl.uniprot.org/citations/31285322 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31285322 | http://www.w3.org/2000/01/rdf-schema#comment | "We derived a mouse model in which a mutant form of Nbn/Nbs1mid8 (hereafter Nbnmid8) exhibits severely impaired binding to the Mre11-Rad50 core of the Mre11 complex. The Nbnmid8 allele was expressed exclusively in hematopoietic lineages (in Nbn-/mid8vav mice). Unlike Nbnflox/floxvav mice with Nbn deficiency in the bone marrow, Nbn-/mid8vav mice were viable. Nbn-/mid8vav mice hematopoiesis was profoundly defective, exhibiting reduced cellularity of thymus and bone marrow, and stage-specific blockage of B cell development. Within 6 mo, Nbn-/mid8 mice developed highly penetrant T cell leukemias. Nbn-/mid8vav leukemias recapitulated mutational features of human T cell acute lymphoblastic leukemia (T-ALL), containing mutations in NOTCH1, TP53, BCL6, BCOR, and IKZF1, suggesting that Nbnmid8 mice may provide a venue to examine the relationship between the Mre11 complex and oncogene activation in the hematopoietic compartment. Genomic analysis of Nbn-/mid8vav malignancies showed focal amplification of 9qA2, causing overexpression of MRE11 and CHK1 We propose that overexpression of MRE11 compensates for the metastable Mre11-Nbnmid8 interaction, and that selective pressure for overexpression reflects the essential role of Nbn in promoting assembly and activity of the Mre11 complex."xsd:string |
| http://purl.uniprot.org/citations/31285322 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1905305116"xsd:string |
| http://purl.uniprot.org/citations/31285322 | http://purl.uniprot.org/core/author | "Kim J.H."xsd:string |
| http://purl.uniprot.org/citations/31285322 | http://purl.uniprot.org/core/author | "Petrini J.H.J."xsd:string |
| http://purl.uniprot.org/citations/31285322 | http://purl.uniprot.org/core/author | "Taylor B.S."xsd:string |
| http://purl.uniprot.org/citations/31285322 | http://purl.uniprot.org/core/author | "Penson A.V."xsd:string |
| http://purl.uniprot.org/citations/31285322 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31285322 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/31285322 | http://purl.uniprot.org/core/pages | "15178-15183"xsd:string |
| http://purl.uniprot.org/citations/31285322 | http://purl.uniprot.org/core/title | "Nbn-Mre11 interaction is required for tumor suppression and genomic integrity."xsd:string |
| http://purl.uniprot.org/citations/31285322 | http://purl.uniprot.org/core/volume | "116"xsd:string |
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