| http://purl.uniprot.org/citations/31293181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31293181 | http://www.w3.org/2000/01/rdf-schema#comment | "Background: Renalase is kidney-derived molecule initially considered as catecholamine-inactivating enzyme. However, recent studies suggest that renalase exerts potent cardio- and nephroprotective actions, not related to its enzymatic activity. Purpose: To assess renalase level in children with chronic kidney disease (CKD). Material and methods: Serum renalase, BMI, arterial stiffness, peripheral and central blood pressure, intima-media thickness (IMT), medications, and biochemical parameters were analyzed in 38 children with CKD (12.23 ± 4.19 years) (stage G2-5). Control group consisted of 38 healthy children. Results: In the study group, GFR was 25.74 ± 8.94 mL/min/1.73 m2; 6 children were dialyzed; 26 had arterial hypertension. Renalase level was higher in the study group compared to control group (p < 0.001). In CKD children renalase correlated (p < 0.05) with BMI Z-score (r = -0.36), alfacalcidol dose (r = 0.41), GFR (r = -0.69), hemoglobin (r = -0.48), total cholesterol (r = 0.35), LDL-cholesterol (r = 0.36), triglycerides (r = 0.52), phosphate (r = 0.35), calcium-phosphorus product (r = 0.35), parathormone (r = 0.58), and pulse wave velocity Z-score (r = 0.42). In multivariate analysis GFR (β = -0.63, p < 0.001), triglycerides (β = 0.59, p = 0.002), and alfacalcidol dose (β = -0.49, p = 0.010) were determinants of renalase. Conclusions: In children with CKD there is a strong correlation between renalase level and CKD stage. Furthermore, in these patients renalase does not correlate with blood pressure but may be a marker of arterial stiffness."xsd:string |
| http://purl.uniprot.org/citations/31293181 | http://purl.org/dc/terms/identifier | "doi:10.1080/1354750x.2019.1642957"xsd:string |
| http://purl.uniprot.org/citations/31293181 | http://purl.uniprot.org/core/author | "Panczyk-Tomaszewska M."xsd:string |
| http://purl.uniprot.org/citations/31293181 | http://purl.uniprot.org/core/author | "Gorska E."xsd:string |
| http://purl.uniprot.org/citations/31293181 | http://purl.uniprot.org/core/author | "Stelmaszczyk-Emmel A."xsd:string |
| http://purl.uniprot.org/citations/31293181 | http://purl.uniprot.org/core/author | "Okarska-Napierala M."xsd:string |
| http://purl.uniprot.org/citations/31293181 | http://purl.uniprot.org/core/author | "Skrzypczyk P."xsd:string |
| http://purl.uniprot.org/citations/31293181 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31293181 | http://purl.uniprot.org/core/name | "Biomarkers"xsd:string |
| http://purl.uniprot.org/citations/31293181 | http://purl.uniprot.org/core/pages | "638-644"xsd:string |
| http://purl.uniprot.org/citations/31293181 | http://purl.uniprot.org/core/title | "Renalase in children with chronic kidney disease."xsd:string |
| http://purl.uniprot.org/citations/31293181 | http://purl.uniprot.org/core/volume | "24"xsd:string |
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