| http://purl.uniprot.org/citations/3129426 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/3129426 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/3129426 | http://www.w3.org/2000/01/rdf-schema#comment | "Mastoparan, a peptide toxin from wasp venom, is a nonspecific secretagogue. We show here that mastoparan increases the GTPase activity and the rate of nucleotide binding of several purified GTP-binding regulatory proteins (G proteins) whose function is to couple cell-surface receptors to intracellular mediators. Mastoparan accelerated guanosine-5'-(3-O-thiotriphosphate binding and consequent G protein activation in part by promoting the dissociation of bound GDP, the mechanism by which receptors regulate G proteins. ADP-ribosylation by pertussis toxin, which uncouples receptors from G proteins, selectively inhibited mastoparan-stimulated activation. Like receptors, mastoparan was more potent if the G protein was reconstituted in phospholipid vesicles and was active at micromolar concentrations of Mg2+. The structure of mastoparan in a lipid bilayer is similar to that predicted for a cationic intracellular loop of G protein-coupled receptors. Mastoparan thus displays a novel mode of toxicity by acting directly on G proteins to mimic the role normally played by agonist-liganded receptors."xsd:string |
| http://purl.uniprot.org/citations/3129426 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0021-9258(18)68669-7"xsd:string |
| http://purl.uniprot.org/citations/3129426 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0021-9258(18)68669-7"xsd:string |
| http://purl.uniprot.org/citations/3129426 | http://purl.uniprot.org/core/author | "Nakajima T."xsd:string |
| http://purl.uniprot.org/citations/3129426 | http://purl.uniprot.org/core/author | "Nakajima T."xsd:string |
| http://purl.uniprot.org/citations/3129426 | http://purl.uniprot.org/core/author | "Ross E.M."xsd:string |
| http://purl.uniprot.org/citations/3129426 | http://purl.uniprot.org/core/author | "Ross E.M."xsd:string |
| http://purl.uniprot.org/citations/3129426 | http://purl.uniprot.org/core/author | "Higashijima T."xsd:string |
| http://purl.uniprot.org/citations/3129426 | http://purl.uniprot.org/core/author | "Higashijima T."xsd:string |
| http://purl.uniprot.org/citations/3129426 | http://purl.uniprot.org/core/author | "Uzu S."xsd:string |
| http://purl.uniprot.org/citations/3129426 | http://purl.uniprot.org/core/author | "Uzu S."xsd:string |
| http://purl.uniprot.org/citations/3129426 | http://purl.uniprot.org/core/date | "1988"xsd:gYear |
| http://purl.uniprot.org/citations/3129426 | http://purl.uniprot.org/core/date | "1988"xsd:gYear |
| http://purl.uniprot.org/citations/3129426 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/3129426 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/3129426 | http://purl.uniprot.org/core/pages | "6491-6494"xsd:string |
| http://purl.uniprot.org/citations/3129426 | http://purl.uniprot.org/core/pages | "6491-6494"xsd:string |
| http://purl.uniprot.org/citations/3129426 | http://purl.uniprot.org/core/title | "Mastoparan, a peptide toxin from wasp venom, mimics receptors by activating GTP-binding regulatory proteins (G proteins)."xsd:string |
| http://purl.uniprot.org/citations/3129426 | http://purl.uniprot.org/core/title | "Mastoparan, a peptide toxin from wasp venom, mimics receptors by activating GTP-binding regulatory proteins (G proteins)."xsd:string |
| http://purl.uniprot.org/citations/3129426 | http://purl.uniprot.org/core/volume | "263"xsd:string |
| http://purl.uniprot.org/citations/3129426 | http://purl.uniprot.org/core/volume | "263"xsd:string |
| http://purl.uniprot.org/citations/3129426 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/3129426 |
| http://purl.uniprot.org/citations/3129426 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/3129426 |