| http://purl.uniprot.org/citations/3129499 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/3129499 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/3129499 | http://www.w3.org/2000/01/rdf-schema#comment | "A cDNA library was constructed from a homozygous B lymphoblastoid cell line (REM) obtained from an individual of a long isolated American Indian tribe, the Warao. The REM cell line expresses serologically defined determinants, DR2 and DQw3, and the T lymphocyte-defined (Dw/LD) specificity, LD-5a. T cells can recognize differences between FJO (a DR2/DQw1 cell line that expresses the Dw specificity MN2) and REM for both DR and DQ molecules. cNDA clones encoding the polymorphic DR beta 1-, DR beta 2-, DQ beta-, and DQ alpha-chains were sequenced and compared with other DR and DQ gene sequences. The DR beta 1-sequence of REM is identical to the DR beta 1-sequence of FJO; the DR beta 2-sequence is also identical to that of FJO except for one amino acid difference at position 67 in the polymorphic first domain (Leu in REM, Phe in FJO) due to a single point mutation. The DQ beta-sequence is identical to that of DR4/DQw3 haplotype; the DQ alpha is different from the DQ alpha of DR4/DQw3 haplotype and identical to the DQ alpha of both the DR3/DQw2 haplotype of a Raji cell line and the DR5/DQw3 haplotype in deduced amino acid sequence. Taken together, these findings suggest that: 1) a single amino acid difference (position 67) in the third hypervariable region of the first domain of the DR beta 2-chain in the DR2 haplotype is apparently sufficient for stimulating T cell responses; 2) the DQw3 serologic specificity may be defined mainly by the DQ beta-rather than DQ alpha-chain; and 3) multiple genetic events have probably occurred to generate the rarely found REM (DR2/LD-5a/DQw3) haplotype."xsd:string |
| http://purl.uniprot.org/citations/3129499 | http://purl.uniprot.org/core/author | "Liu C.P."xsd:string |
| http://purl.uniprot.org/citations/3129499 | http://purl.uniprot.org/core/author | "Liu C.P."xsd:string |
| http://purl.uniprot.org/citations/3129499 | http://purl.uniprot.org/core/author | "Bach F.H."xsd:string |
| http://purl.uniprot.org/citations/3129499 | http://purl.uniprot.org/core/author | "Bach F.H."xsd:string |
| http://purl.uniprot.org/citations/3129499 | http://purl.uniprot.org/core/author | "Wu S.K."xsd:string |
| http://purl.uniprot.org/citations/3129499 | http://purl.uniprot.org/core/author | "Wu S.K."xsd:string |
| http://purl.uniprot.org/citations/3129499 | http://purl.uniprot.org/core/date | "1988"xsd:gYear |
| http://purl.uniprot.org/citations/3129499 | http://purl.uniprot.org/core/date | "1988"xsd:gYear |
| http://purl.uniprot.org/citations/3129499 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/3129499 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/3129499 | http://purl.uniprot.org/core/pages | "3631-3639"xsd:string |
| http://purl.uniprot.org/citations/3129499 | http://purl.uniprot.org/core/pages | "3631-3639"xsd:string |
| http://purl.uniprot.org/citations/3129499 | http://purl.uniprot.org/core/title | "Molecular studies of a rare DR2/LD-5a/DQw3 HLA class II haplotype. Multiple genetic mechanisms in the generation of polymorphic HLA class II genes."xsd:string |
| http://purl.uniprot.org/citations/3129499 | http://purl.uniprot.org/core/title | "Molecular studies of a rare DR2/LD-5a/DQw3 HLA class II haplotype. Multiple genetic mechanisms in the generation of polymorphic HLA class II genes."xsd:string |
| http://purl.uniprot.org/citations/3129499 | http://purl.uniprot.org/core/volume | "140"xsd:string |
| http://purl.uniprot.org/citations/3129499 | http://purl.uniprot.org/core/volume | "140"xsd:string |
| http://purl.uniprot.org/citations/3129499 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/3129499 |
| http://purl.uniprot.org/citations/3129499 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/3129499 |
| http://purl.uniprot.org/citations/3129499 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/3129499 |
| http://purl.uniprot.org/citations/3129499 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/3129499 |
| http://purl.uniprot.org/citations/3129499 | http://purl.uniprot.org/core/erratum | http://purl.uniprot.org/citations/SIP223122F6F2438CC8 |
| http://purl.uniprot.org/uniprot/P01911 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/3129499 |