| http://purl.uniprot.org/citations/31300538 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31300538 | http://www.w3.org/2000/01/rdf-schema#comment | "The roles of cellular orientation during trabecular and ventricular wall morphogenesis are unknown, and so are the underlying mechanisms that regulate cellular orientation. Myocardial-specific Numb and Numblike double-knockout (MDKO) hearts display a variety of defects, including in cellular orientation, patterns of mitotic spindle orientation, trabeculation, and ventricular compaction. Furthermore, Numb- and Numblike-null cardiomyocytes exhibit cellular behaviors distinct from those of control cells during trabecular morphogenesis based on single-cell lineage tracing. We investigated how Numb regulates cellular orientation and behaviors and determined that N-cadherin levels and membrane localization are reduced in MDKO hearts. To determine how Numb regulates N-cadherin membrane localization, we generated an mCherry:Numb knockin line and found that Numb localized to diverse endocytic organelles but mainly to the recycling endosome. Consistent with this localization, cardiomyocytes in MDKO did not display defects in N-cadherin internalization but rather in postendocytic recycling to the plasma membrane. Furthermore, N-cadherin overexpression via a mosaic model partially rescued the defects in cellular orientation and trabeculation of MDKO hearts. Our study unravels a phenomenon that cardiomyocytes display spatiotemporal cellular orientation during ventricular wall morphogenesis, and its disruption leads to abnormal trabecular and ventricular wall morphogenesis. Furthermore, we established a mechanism by which Numb modulates cellular orientation and consequently trabecular and ventricular wall morphogenesis by regulating N-cadherin recycling to the plasma membrane."xsd:string |
| http://purl.uniprot.org/citations/31300538 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1904684116"xsd:string |
| http://purl.uniprot.org/citations/31300538 | http://purl.uniprot.org/core/author | "Huang G."xsd:string |
| http://purl.uniprot.org/citations/31300538 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/31300538 | http://purl.uniprot.org/core/author | "Lu Y."xsd:string |
| http://purl.uniprot.org/citations/31300538 | http://purl.uniprot.org/core/author | "Li J.'"xsd:string |
| http://purl.uniprot.org/citations/31300538 | http://purl.uniprot.org/core/author | "Wu M."xsd:string |
| http://purl.uniprot.org/citations/31300538 | http://purl.uniprot.org/core/author | "Zhong W."xsd:string |
| http://purl.uniprot.org/citations/31300538 | http://purl.uniprot.org/core/author | "Miao L."xsd:string |
| http://purl.uniprot.org/citations/31300538 | http://purl.uniprot.org/core/author | "Schwarz J.J."xsd:string |
| http://purl.uniprot.org/citations/31300538 | http://purl.uniprot.org/core/author | "Vincent P.A."xsd:string |
| http://purl.uniprot.org/citations/31300538 | http://purl.uniprot.org/core/author | "Fan Z.C."xsd:string |
| http://purl.uniprot.org/citations/31300538 | http://purl.uniprot.org/core/author | "Barroso M."xsd:string |
| http://purl.uniprot.org/citations/31300538 | http://purl.uniprot.org/core/author | "Xin H.B."xsd:string |
| http://purl.uniprot.org/citations/31300538 | http://purl.uniprot.org/core/author | "Singer H.A."xsd:string |
| http://purl.uniprot.org/citations/31300538 | http://purl.uniprot.org/core/author | "Radice G.L."xsd:string |
| http://purl.uniprot.org/citations/31300538 | http://purl.uniprot.org/core/author | "Mazurkiewicz J.E."xsd:string |
| http://purl.uniprot.org/citations/31300538 | http://purl.uniprot.org/core/author | "Wan L.Q."xsd:string |
| http://purl.uniprot.org/citations/31300538 | http://purl.uniprot.org/core/author | "Shieh D."xsd:string |
| http://purl.uniprot.org/citations/31300538 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31300538 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/31300538 | http://purl.uniprot.org/core/pages | "15560-15569"xsd:string |
| http://purl.uniprot.org/citations/31300538 | http://purl.uniprot.org/core/title | "Cardiomyocyte orientation modulated by the Numb family proteins-N-cadherin axis is essential for ventricular wall morphogenesis."xsd:string |
| http://purl.uniprot.org/citations/31300538 | http://purl.uniprot.org/core/volume | "116"xsd:string |