| http://purl.uniprot.org/citations/31302118 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31302118 | http://www.w3.org/2000/01/rdf-schema#comment | "Sick sinus syndrome (SSS) is primarily a disease of the elderly, and age-dependent decrease in Cav1.2 and Cav1.3 Ca2+ channels within the sinus node has been shown to play an important role in sinoatrial node (SAN) degeneration; however, posttranscriptional mechanisms regulating decrease in Cav1.2 and Cav1.3 Ca2+ channels remain unclear. Some studies have reported that microRNAs (miRNAs) are involved in age-related cardiovascular diseases. Nevertheless, little is known about the roles of miRNAs in age-related SSS. This study investigated whether miR-1976 was involved in the regulation of SAN degeneration by targeting Cav1.2 and Cav1.3 Ca2+ channels. First, using microarray-based miRNA expression profiling and qRT-PCR, we confirmed that miR-1976 was upregulated in the plasma of patients with age-related SSS relative to healthy controls. By employing target gene prediction software, luciferase assay and western blotting, we further confirmed Cav1.2 and Cav1.3 as direct targets of miR-1976. Furthermore, miR-1976 levels in rabbit SAN tissues were negatively correlated with Cav1.2 and Cav1.3 expression and intrinsic heart rates but positively correlated with corrected sinus node recovery time (CSNRT). Additionally, miR-1976 transgenic mice displayed attenuated Cav1.2 and Cav1.3 protein expression, which led to sinus node dysfunction. These results suggest that miR-1976 plays an important role in the SAN aging process by targeting Cav1.2 and Cav1.3. Thus, miR-1976 could have great potential as a noninvasive diagnostic tool and therapeutic target for SSS. These findings may reveal important insights into the pathogenesis of SSS."xsd:string |
| http://purl.uniprot.org/citations/31302118 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.yjmcc.2019.06.018"xsd:string |
| http://purl.uniprot.org/citations/31302118 | http://purl.uniprot.org/core/author | "Ding L."xsd:string |
| http://purl.uniprot.org/citations/31302118 | http://purl.uniprot.org/core/author | "Fan J."xsd:string |
| http://purl.uniprot.org/citations/31302118 | http://purl.uniprot.org/core/author | "Liu R."xsd:string |
| http://purl.uniprot.org/citations/31302118 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/31302118 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/31302118 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/31302118 | http://purl.uniprot.org/core/author | "Wei F."xsd:string |
| http://purl.uniprot.org/citations/31302118 | http://purl.uniprot.org/core/author | "Yu L."xsd:string |
| http://purl.uniprot.org/citations/31302118 | http://purl.uniprot.org/core/author | "Yang B."xsd:string |
| http://purl.uniprot.org/citations/31302118 | http://purl.uniprot.org/core/author | "Kuang X."xsd:string |
| http://purl.uniprot.org/citations/31302118 | http://purl.uniprot.org/core/author | "Jiao B."xsd:string |
| http://purl.uniprot.org/citations/31302118 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31302118 | http://purl.uniprot.org/core/name | "J Mol Cell Cardiol"xsd:string |
| http://purl.uniprot.org/citations/31302118 | http://purl.uniprot.org/core/pages | "74-85"xsd:string |
| http://purl.uniprot.org/citations/31302118 | http://purl.uniprot.org/core/title | "MicroRNA-1976 regulates degeneration of the sinoatrial node by targeting Cav1.2 and Cav1.3 ion channels."xsd:string |
| http://purl.uniprot.org/citations/31302118 | http://purl.uniprot.org/core/volume | "134"xsd:string |
| http://purl.uniprot.org/citations/31302118 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31302118 |
| http://purl.uniprot.org/citations/31302118 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31302118 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MR67-mappedCitation-31302118 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31302118 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MSA1-mappedCitation-31302118 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31302118 |
| http://purl.uniprot.org/uniprot/#_E9PDI6-mappedCitation-31302118 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31302118 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GUN6-mappedCitation-31302118 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31302118 |