| http://purl.uniprot.org/citations/31307406 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31307406 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundThe protease uPA and its inhibitor PAI-1 play major roles in hemostasis and are also involved in cancer progression. This is mainly caused by their ability to degrade extracellular matrix-facilitating tumor cell migration. This study aimed to investigate the impact of uPA/PAI-1 and disseminated cytokeratin-positive cells (dCK+) on the outcome and the existence of synergistic effects.MethodsWe retrospectively analyzed a cohort of 480 breast cancer cases with known uPA/PAI-1 and dCK+ status. uPA/PAI-1 was tested on fresh tumor samples using a commercial ELISA test. Bone marrow aspirates were investigated immunocytochemically for CK18.ResultsDCK+ cells were identified in 23% of cases. uPA positivity was significantly associated with the occurrence of dCK+ cells (P = 0.028). uPA and PAI-1 were significantly associated with outcome in the subgroup of early-stage cases without chemotherapy. DCK+ cells alone were not prognostic. However, we found synergistic effects. In the subgroup of node-negative cases with and without chemotherapy, the prognostic impact of uPA and PAI-1 was enhanced in cases with additional dCK-positivity (triple +). In cases without chemotherapy, triple-positive status was independently prognostic (HR: 9.3 CI: 1.1-75) next to T stage.ConclusionsuPA and PAI-1 seem to influence the metastatic potential of dCK+ cells, which underlines its important role in tumor progression."xsd:string |
| http://purl.uniprot.org/citations/31307406 | http://purl.org/dc/terms/identifier | "doi:10.1186/s12885-019-5857-0"xsd:string |
| http://purl.uniprot.org/citations/31307406 | http://purl.uniprot.org/core/author | "Hoffmann R."xsd:string |
| http://purl.uniprot.org/citations/31307406 | http://purl.uniprot.org/core/author | "Jung T."xsd:string |
| http://purl.uniprot.org/citations/31307406 | http://purl.uniprot.org/core/author | "Harbeck N."xsd:string |
| http://purl.uniprot.org/citations/31307406 | http://purl.uniprot.org/core/author | "Jakubowicz E."xsd:string |
| http://purl.uniprot.org/citations/31307406 | http://purl.uniprot.org/core/author | "Schlimok G."xsd:string |
| http://purl.uniprot.org/citations/31307406 | http://purl.uniprot.org/core/author | "Markl B."xsd:string |
| http://purl.uniprot.org/citations/31307406 | http://purl.uniprot.org/core/author | "Oruzio D."xsd:string |
| http://purl.uniprot.org/citations/31307406 | http://purl.uniprot.org/core/author | "Schenkirsch G."xsd:string |
| http://purl.uniprot.org/citations/31307406 | http://purl.uniprot.org/core/author | "Kazik M."xsd:string |
| http://purl.uniprot.org/citations/31307406 | http://purl.uniprot.org/core/author | "Steinfeld D."xsd:string |
| http://purl.uniprot.org/citations/31307406 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31307406 | http://purl.uniprot.org/core/name | "BMC Cancer"xsd:string |
| http://purl.uniprot.org/citations/31307406 | http://purl.uniprot.org/core/pages | "692"xsd:string |
| http://purl.uniprot.org/citations/31307406 | http://purl.uniprot.org/core/title | "Impact of uPA/PAI-1 and disseminated cytokeratin-positive cells in breast cancer."xsd:string |
| http://purl.uniprot.org/citations/31307406 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/31307406 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31307406 |
| http://purl.uniprot.org/citations/31307406 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31307406 |
| http://purl.uniprot.org/uniprot/#_B2R7F2-mappedCitation-31307406 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31307406 |
| http://purl.uniprot.org/uniprot/#_B4DNJ4-mappedCitation-31307406 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31307406 |
| http://purl.uniprot.org/uniprot/#_P00749-mappedCitation-31307406 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31307406 |
| http://purl.uniprot.org/uniprot/#_Q5PY49-mappedCitation-31307406 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31307406 |
| http://purl.uniprot.org/uniprot/#_Q59GZ8-mappedCitation-31307406 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31307406 |