| http://purl.uniprot.org/citations/31308265 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31308265 | http://www.w3.org/2000/01/rdf-schema#comment | "Aberrant expressions of various long non-coding RNAs (lncRNAs) have been involved in the progression and pathogenesis of various carcinomas. However, the expression and biological function of SLCO4A1-AS1 in colorectal cancer (CRC) remain poorly understood. Gain- and loss-of-function assays were applied to determine the roles of SLCO4A1-AS1 in autophagy and CRC progression. qRT-PCR and in situ hybridization (ISH) results showed that SLCO4A1-AS1 was positively associated with PARD3 expression in CRC tissues. In vitro and in vivo studies revealed that SLCO4A1-AS1 knockdown repressed cytoprotective autophagy as assayed by transmission electron microscopy (TEM), and inhibited cell proliferation by directly targeting partition-defective 3 (PARD3). Mechanistically, SLCO4A1-AS1 acted as a sponge of miR-508-3p, leading to upregulation of PARD3 and promotion of CRC cell proliferation. The current study demonstrates that the SLCO4A1-AS1/miR-508-3p/PARD3/autophagy pathway play a critical role in CRC cell proliferation, and might provide novel targets for developing therapeutic strategies for CRC."xsd:string |
| http://purl.uniprot.org/citations/31308265 | http://purl.org/dc/terms/identifier | "doi:10.18632/aging.102081"xsd:string |
| http://purl.uniprot.org/citations/31308265 | http://purl.uniprot.org/core/author | "Jin J."xsd:string |
| http://purl.uniprot.org/citations/31308265 | http://purl.uniprot.org/core/author | "Wang Z."xsd:string |
| http://purl.uniprot.org/citations/31308265 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31308265 | http://purl.uniprot.org/core/name | "Aging (Albany NY)"xsd:string |
| http://purl.uniprot.org/citations/31308265 | http://purl.uniprot.org/core/pages | "4876-4889"xsd:string |
| http://purl.uniprot.org/citations/31308265 | http://purl.uniprot.org/core/title | "LncRNA SLCO4A1-AS1 promotes colorectal cancer cell proliferation by enhancing autophagy via miR-508-3p/PARD3 axis."xsd:string |
| http://purl.uniprot.org/citations/31308265 | http://purl.uniprot.org/core/volume | "11"xsd:string |
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