| http://purl.uniprot.org/citations/31315906 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31315906 | http://www.w3.org/2000/01/rdf-schema#comment | "Long noncoding RNAs (lncRNAs) can regulate the activity of target genes by participating in the organization of chromatin architecture. We have devised a "chromatin-RNA in situ reverse transcription sequencing" (CRIST-seq) approach to profile the lncRNA interaction network in gene regulatory elements by combining the simplicity of RNA biotin labeling with the specificity of the CRISPR/Cas9 system. Using gene-specific gRNAs, we describe a pluripotency-specific lncRNA interacting network in the promoters of Sox2 and Pou5f1, two critical stem cell factors that are required for the maintenance of pluripotency. The promoter-interacting lncRNAs were specifically activated during reprogramming into pluripotency. Knockdown of these lncRNAs caused the stem cells to exit from pluripotency. In contrast, overexpression of the pluripotency-associated lncRNA activated the promoters of core stem cell factor genes and enhanced fibroblast reprogramming into pluripotency. These CRIST-seq data suggest that the Sox2 and Pou5f1 promoters are organized within a unique lncRNA interaction network that determines the fate of pluripotency during reprogramming. This CRIST approach may be broadly used to map lncRNA interaction networks at target loci across the genome."xsd:string |
| http://purl.uniprot.org/citations/31315906 | http://purl.org/dc/terms/identifier | "doi:10.1101/gr.244996.118"xsd:string |
| http://purl.uniprot.org/citations/31315906 | http://purl.uniprot.org/core/author | "Chen J."xsd:string |
| http://purl.uniprot.org/citations/31315906 | http://purl.uniprot.org/core/author | "Chen R."xsd:string |
| http://purl.uniprot.org/citations/31315906 | http://purl.uniprot.org/core/author | "Du Z."xsd:string |
| http://purl.uniprot.org/citations/31315906 | http://purl.uniprot.org/core/author | "Chen H."xsd:string |
| http://purl.uniprot.org/citations/31315906 | http://purl.uniprot.org/core/author | "Chen N."xsd:string |
| http://purl.uniprot.org/citations/31315906 | http://purl.uniprot.org/core/author | "Cui X."xsd:string |
| http://purl.uniprot.org/citations/31315906 | http://purl.uniprot.org/core/author | "Liu Z."xsd:string |
| http://purl.uniprot.org/citations/31315906 | http://purl.uniprot.org/core/author | "Luo J."xsd:string |
| http://purl.uniprot.org/citations/31315906 | http://purl.uniprot.org/core/author | "Li W."xsd:string |
| http://purl.uniprot.org/citations/31315906 | http://purl.uniprot.org/core/author | "Hao Y."xsd:string |
| http://purl.uniprot.org/citations/31315906 | http://purl.uniprot.org/core/author | "Qin B."xsd:string |
| http://purl.uniprot.org/citations/31315906 | http://purl.uniprot.org/core/author | "Wang C."xsd:string |
| http://purl.uniprot.org/citations/31315906 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/31315906 | http://purl.uniprot.org/core/author | "Xu W."xsd:string |
| http://purl.uniprot.org/citations/31315906 | http://purl.uniprot.org/core/author | "Zhou L."xsd:string |
| http://purl.uniprot.org/citations/31315906 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/31315906 | http://purl.uniprot.org/core/author | "Zhang S."xsd:string |
| http://purl.uniprot.org/citations/31315906 | http://purl.uniprot.org/core/author | "Wen X."xsd:string |
| http://purl.uniprot.org/citations/31315906 | http://purl.uniprot.org/core/author | "Yu D."xsd:string |
| http://purl.uniprot.org/citations/31315906 | http://purl.uniprot.org/core/author | "Ay F."xsd:string |
| http://purl.uniprot.org/citations/31315906 | http://purl.uniprot.org/core/author | "Cui J."xsd:string |
| http://purl.uniprot.org/citations/31315906 | http://purl.uniprot.org/core/author | "Jia L."xsd:string |