| http://purl.uniprot.org/citations/31320629 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31320629 | http://www.w3.org/2000/01/rdf-schema#comment | "Neuronal precursor cell expressed developmentally downregulated 4-2 (NEDD4-2) is an E3 ubiquitin ligase to regulate ion transport by controlling cellular trafficking/endocytosis and lysosomal degradation of ion channels and transporters. Thus, NEDD4-2 is relevant to neuronal excitability and epileptic encephalopathies in human patients. However, the regulatory molecules for NEDD4-2 dephosphorylation have been still elusive. Here, we demonstrate that pyridoxal-5'-phosphate phosphatase/chronophin (PLPP/CIN) specifically dephosphorylated NEDD4-2 serine (S) 448 site. PLPP/CIN deletion inhibited NEDD4-2 ubiquitination, and diminished the responsiveness of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) by facilitating NEDD4-2-mediated ubiquitination of GluA1 subunit under physiological condition. PLPP/CIN overexpression reversed these effects. These PLPP/CIN-mediated processes were required for the increased seizure severity and its progression in response to kainic acid (KA). Therefore, we suggest the novel function of PLPP/CIN as a NEDD4-2 phosphatase, which may be a potential therapeutic target for NEDD4-2-associated diseases as well as various neurological and psychiatric disorders, including epilepsy."xsd:string |
| http://purl.uniprot.org/citations/31320629 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41419-019-1781-0"xsd:string |
| http://purl.uniprot.org/citations/31320629 | http://purl.uniprot.org/core/author | "Lee D.S."xsd:string |
| http://purl.uniprot.org/citations/31320629 | http://purl.uniprot.org/core/author | "Kim M.J."xsd:string |
| http://purl.uniprot.org/citations/31320629 | http://purl.uniprot.org/core/author | "Kim J.E."xsd:string |
| http://purl.uniprot.org/citations/31320629 | http://purl.uniprot.org/core/author | "Kang T.C."xsd:string |
| http://purl.uniprot.org/citations/31320629 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31320629 | http://purl.uniprot.org/core/name | "Cell Death Dis"xsd:string |
| http://purl.uniprot.org/citations/31320629 | http://purl.uniprot.org/core/pages | "545"xsd:string |
| http://purl.uniprot.org/citations/31320629 | http://purl.uniprot.org/core/title | "PLPP/CIN-mediated NEDD4-2 S448 dephosphorylation regulates neuronal excitability via GluA1 ubiquitination."xsd:string |
| http://purl.uniprot.org/citations/31320629 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/31320629 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31320629 |
| http://purl.uniprot.org/citations/31320629 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31320629 |
| http://purl.uniprot.org/uniprot/#_P60487-mappedCitation-31320629 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31320629 |
| http://purl.uniprot.org/uniprot/#_Q5U5Y4-mappedCitation-31320629 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31320629 |
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| http://purl.uniprot.org/uniprot/Q9JJ90 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31320629 |
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| http://purl.uniprot.org/uniprot/P60487 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31320629 |