| http://purl.uniprot.org/citations/31331966 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31331966 | http://www.w3.org/2000/01/rdf-schema#comment | "Here, we show that cells expressing the adherens junction protein nectin-1 capture nectin-4-containing membranes from the surface of adjacent cells in a trans-endocytosis process. We find that internalized nectin-1-nectin-4 complexes follow the endocytic pathway. The nectin-1 cytoplasmic tail controls transfer: its deletion prevents trans-endocytosis, while its exchange with the nectin-4 tail reverses transfer direction. Nectin-1-expressing cells acquire dye-labeled cytoplasmic proteins synchronously with nectin-4, a process most active during cell adhesion. Some cytoplasmic cargo remains functional after transfer, as demonstrated with encapsidated genomes of measles virus (MeV). This virus uses nectin-4, but not nectin-1, as a receptor. Epithelial cells expressing nectin-4, but not those expressing another MeV receptor in its place, can transfer infection to nectin-1-expressing primary neurons. Thus, this newly discovered process can move cytoplasmic cargo, including infectious material, from epithelial cells to neurons. We name the process nectin-elicited cytoplasm transfer (NECT). NECT-related trans-endocytosis processes may be exploited by pathogens to extend tropism. This article has an associated First Person interview with the first author of the paper."xsd:string |
| http://purl.uniprot.org/citations/31331966 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.235507"xsd:string |
| http://purl.uniprot.org/citations/31331966 | http://purl.uniprot.org/core/author | "Honig B."xsd:string |
| http://purl.uniprot.org/citations/31331966 | http://purl.uniprot.org/core/author | "Cattaneo R."xsd:string |
| http://purl.uniprot.org/citations/31331966 | http://purl.uniprot.org/core/author | "Shapiro L."xsd:string |
| http://purl.uniprot.org/citations/31331966 | http://purl.uniprot.org/core/author | "Pfaller C.K."xsd:string |
| http://purl.uniprot.org/citations/31331966 | http://purl.uniprot.org/core/author | "Billadeau D.D."xsd:string |
| http://purl.uniprot.org/citations/31331966 | http://purl.uniprot.org/core/author | "Mateo M."xsd:string |
| http://purl.uniprot.org/citations/31331966 | http://purl.uniprot.org/core/author | "Navaratnarajah C.K."xsd:string |
| http://purl.uniprot.org/citations/31331966 | http://purl.uniprot.org/core/author | "Taylor M.P."xsd:string |
| http://purl.uniprot.org/citations/31331966 | http://purl.uniprot.org/core/author | "Harrison O.J."xsd:string |
| http://purl.uniprot.org/citations/31331966 | http://purl.uniprot.org/core/author | "Troyanovsky R.B."xsd:string |
| http://purl.uniprot.org/citations/31331966 | http://purl.uniprot.org/core/author | "Troyanovsky S.M."xsd:string |
| http://purl.uniprot.org/citations/31331966 | http://purl.uniprot.org/core/author | "Alekhina O."xsd:string |
| http://purl.uniprot.org/citations/31331966 | http://purl.uniprot.org/core/author | "Sergeeva A.P."xsd:string |
| http://purl.uniprot.org/citations/31331966 | http://purl.uniprot.org/core/author | "Thornburg T."xsd:string |
| http://purl.uniprot.org/citations/31331966 | http://purl.uniprot.org/core/author | "Kochetkova I."xsd:string |
| http://purl.uniprot.org/citations/31331966 | http://purl.uniprot.org/core/author | "Donohue R.C."xsd:string |
| http://purl.uniprot.org/citations/31331966 | http://purl.uniprot.org/core/author | "Indra I."xsd:string |
| http://purl.uniprot.org/citations/31331966 | http://purl.uniprot.org/core/author | "Generous A.R."xsd:string |
| http://purl.uniprot.org/citations/31331966 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31331966 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/31331966 | http://purl.uniprot.org/core/pages | "jcs235507"xsd:string |
| http://purl.uniprot.org/citations/31331966 | http://purl.uniprot.org/core/title | "Trans-endocytosis elicited by nectins transfers cytoplasmic cargo, including infectious material, between cells."xsd:string |