| http://purl.uniprot.org/citations/31344454 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31344454 | http://www.w3.org/2000/01/rdf-schema#comment | "Mitochondrial DNA (mtDNA) mutations are thought to have a causal role in a variety of age-related neurodegenerative diseases, including age-related hearing loss (AHL). In the current study, we investigated the roles of mtDNA deletions and point mutations in AHL in mitochondrial mutator mice (Polgmut/mut) that were backcrossed onto CBA/CaJ mice, a well-established model of late-onset AHL. mtDNA deletions accumulated significantly with age in the inner ears of Polgmut/mut mice, while there were no differences in mtDNA deletion frequencies in the inner ears between 5 and 17 months old Polg+/+ mice or 5 months old Polg+/+ and Polgmut/mut mice. mtDNA deletions also accumulated significantly in the inner ears of CBA/CaJ mice during normal aging. In contrast, 5 months old Polgmut/mut mice displayed a 238-fold increase in mtDNA point mutation frequencies in the inner ears compared to age-matched Polg+/+ mice, but there were no differences in mtDNA point mutation frequencies in the inner ears between 5 and 17 months old Polgmut/mut mice. Seventeen-month-old Polgmut/mut mice also displayed early-onset severe hearing loss associated with a significant reduction in neural output of the cochlea, while age-matched Polg+/+ mice displayed little or no hearing impairment. Consistent with the physiological and mtDNA deletion test result, 17-month-old Polgmut/mut mice displayed a profound loss of spiral ganglion neurons in the cochlea. Thus, our data suggest that a higher burden of mtDNA point mutations from a young age and age-related accumulation of mtDNA deletions likely contribute to early-onset AHL in mitochondrial mutator mice."xsd:string |
| http://purl.uniprot.org/citations/31344454 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.exger.2019.110675"xsd:string |
| http://purl.uniprot.org/citations/31344454 | http://purl.uniprot.org/core/author | "Han C."xsd:string |
| http://purl.uniprot.org/citations/31344454 | http://purl.uniprot.org/core/author | "Liu L."xsd:string |
| http://purl.uniprot.org/citations/31344454 | http://purl.uniprot.org/core/author | "Kim M.J."xsd:string |
| http://purl.uniprot.org/citations/31344454 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/31344454 | http://purl.uniprot.org/core/author | "Tanokura M."xsd:string |
| http://purl.uniprot.org/citations/31344454 | http://purl.uniprot.org/core/author | "White K."xsd:string |
| http://purl.uniprot.org/citations/31344454 | http://purl.uniprot.org/core/author | "Evans K."xsd:string |
| http://purl.uniprot.org/citations/31344454 | http://purl.uniprot.org/core/author | "Ding D."xsd:string |
| http://purl.uniprot.org/citations/31344454 | http://purl.uniprot.org/core/author | "Chen G.D."xsd:string |
| http://purl.uniprot.org/citations/31344454 | http://purl.uniprot.org/core/author | "Park H.J."xsd:string |
| http://purl.uniprot.org/citations/31344454 | http://purl.uniprot.org/core/author | "Boyd K."xsd:string |
| http://purl.uniprot.org/citations/31344454 | http://purl.uniprot.org/core/author | "Linser P.J."xsd:string |
| http://purl.uniprot.org/citations/31344454 | http://purl.uniprot.org/core/author | "Someya S."xsd:string |
| http://purl.uniprot.org/citations/31344454 | http://purl.uniprot.org/core/author | "Salvi R."xsd:string |
| http://purl.uniprot.org/citations/31344454 | http://purl.uniprot.org/core/author | "Haroon S."xsd:string |
| http://purl.uniprot.org/citations/31344454 | http://purl.uniprot.org/core/author | "Prolla T."xsd:string |
| http://purl.uniprot.org/citations/31344454 | http://purl.uniprot.org/core/author | "Vermulst M."xsd:string |
| http://purl.uniprot.org/citations/31344454 | http://purl.uniprot.org/core/author | "Wanagat J."xsd:string |
| http://purl.uniprot.org/citations/31344454 | http://purl.uniprot.org/core/author | "Caicedo I."xsd:string |
| http://purl.uniprot.org/citations/31344454 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31344454 | http://purl.uniprot.org/core/name | "Exp Gerontol"xsd:string |
| http://purl.uniprot.org/citations/31344454 | http://purl.uniprot.org/core/pages | "110675"xsd:string |