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| http://purl.uniprot.org/citations/31348911 | http://www.w3.org/2000/01/rdf-schema#comment | "Although it is known that acetylcholine acting through M1 muscarinic receptors (M1Rs) is essential for memory consolidation in the anterior basolateral nucleus of the amygdala (BLa), virtually nothing is known about the circuits involved. In the hippocampus M1R activation facilitates long-term potentiation (LTP) by potentiating NMDA glutamate receptor (NMDAR) currents. The majority of NMDAR+ profiles in the BLa are spines. Since about half of dendritic spines of BLa pyramidal neurons (PNs) receiving glutamatergic inputs are M1R-immunoreactive (M1R+) it is possible that the role of M1Rs in BLa mnemonic functions also involves potentiation of NMDAR currents in spines. However, the finding that only about half of BLa spines are M1R+ suggests that this proposed mechanism may only apply to a subset of glutamatergic inputs. As a first step in the identification of differential glutamatergic inputs to M1R+ spines in the BLa, the present electron microscopic study used antibodies to two different vesicular glutamate transporter proteins (VGluTs) to label two different subsets of glutamatergic inputs to M1R+ spines. These inputs are largely complimentary with VGluT1+ inputs arising mainly from cortical structures and the basolateral nucleus, and VGluT2+ inputs arising mainly from the thalamus. It was found that about one-half of the spines that were postsynaptic to VGluT1+ or VGluT2+ terminals were M1R+. In addition, a subset of the VGluT1+ or VGluT2+ axon terminals were M1R+, including those that synapsed with M1R+ spines. These results suggest that acetylcholine can modulate glutamatergic inputs to BLa spines by presynaptic as well as postsynaptic M1R-mediated mechanisms."xsd:string |
| http://purl.uniprot.org/citations/31348911 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.brainres.2019.146349"xsd:string |
| http://purl.uniprot.org/citations/31348911 | http://purl.uniprot.org/core/author | "McDonald A.J."xsd:string |
| http://purl.uniprot.org/citations/31348911 | http://purl.uniprot.org/core/author | "Jones G.C."xsd:string |
| http://purl.uniprot.org/citations/31348911 | http://purl.uniprot.org/core/author | "Mott D.D."xsd:string |
| http://purl.uniprot.org/citations/31348911 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31348911 | http://purl.uniprot.org/core/name | "Brain Res"xsd:string |
| http://purl.uniprot.org/citations/31348911 | http://purl.uniprot.org/core/pages | "146349"xsd:string |
| http://purl.uniprot.org/citations/31348911 | http://purl.uniprot.org/core/title | "Diverse glutamatergic inputs target spines expressing M1 muscarinic receptors in the basolateral amygdala: An ultrastructural analysis."xsd:string |
| http://purl.uniprot.org/citations/31348911 | http://purl.uniprot.org/core/volume | "1722"xsd:string |
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