| http://purl.uniprot.org/citations/31366666 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31366666 | http://www.w3.org/2000/01/rdf-schema#comment | "Nuclear pore complexes have emerged in recent years as chromatin-binding nuclear scaffolds, able to influence target gene expression. However, how nucleoporins (Nups) exert this control remains poorly understood. Here we show that ectopically tethering Drosophila Nups, especially Sec13, to chromatin is sufficient to induce chromatin decondensation. This decondensation is mediated through chromatin-remodeling complex PBAP, as PBAP is both robustly recruited by Sec13 and required for Sec13-induced decondensation. This phenomenon is not correlated with localization of the target locus to the nuclear periphery, but is correlated with robust recruitment of Nup Elys. Furthermore, we identified a biochemical interaction between endogenous Sec13 and Elys with PBAP, and a role for endogenous Elys in global as well as gene-specific chromatin decompaction. Together, these findings reveal a functional role and mechanism for specific nuclear pore components in promoting an open chromatin state."xsd:string |
| http://purl.uniprot.org/citations/31366666 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.201807139"xsd:string |
| http://purl.uniprot.org/citations/31366666 | http://purl.uniprot.org/core/author | "Gozalo A."xsd:string |
| http://purl.uniprot.org/citations/31366666 | http://purl.uniprot.org/core/author | "Capelson M."xsd:string |
| http://purl.uniprot.org/citations/31366666 | http://purl.uniprot.org/core/author | "Pascual-Garcia P."xsd:string |
| http://purl.uniprot.org/citations/31366666 | http://purl.uniprot.org/core/author | "Little S.C."xsd:string |
| http://purl.uniprot.org/citations/31366666 | http://purl.uniprot.org/core/author | "Kuhn T.M."xsd:string |
| http://purl.uniprot.org/citations/31366666 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31366666 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/31366666 | http://purl.uniprot.org/core/pages | "2945-2961"xsd:string |
| http://purl.uniprot.org/citations/31366666 | http://purl.uniprot.org/core/title | "Chromatin targeting of nuclear pore proteins induces chromatin decondensation."xsd:string |
| http://purl.uniprot.org/citations/31366666 | http://purl.uniprot.org/core/volume | "218"xsd:string |
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