| http://purl.uniprot.org/citations/31371377 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31371377 | http://www.w3.org/2000/01/rdf-schema#comment | "Drosophila photoreceptors develop from polarized epithelial cells that have apical and basolateral membranes. During morphogenesis, the apical membranes subdivide into a united bundle of photosensory microvilli (rhabdomeres) and a surrounding supporting membrane (stalk). By EMS-induced mutagenesis screening, we found that the F-Bin/Amphiphysin/Rvs (F-BAR) protein syndapin is essential for apical membrane segregation. The analysis of the super-resolution microscopy, STORM and the electron microscopy suggest that syndapin localizes to the neck of the microvilli at the base of the rhabdomere. Syndapin and moesin are required to constrict the neck of the microvilli to organize the membrane architecture at the base of the rhabdomere, to exclude the stalk membrane. Simultaneous loss of syndapin along with the microvilli adhesion molecule chaoptin significantly enhanced the disruption of stalk-rhabdomere segregation. However, loss of the factors involving endocytosis do not interfere. These results indicated syndapin is most likely functioning through its membrane curvature properties, and not through endocytic processes for stalk-rhabdomere segregation. Elucidation of the mechanism of this unconventional domain formation will provide novel insights into the field of cell biology."xsd:string |
| http://purl.uniprot.org/citations/31371377 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.169292"xsd:string |
| http://purl.uniprot.org/citations/31371377 | http://purl.uniprot.org/core/author | "Liu Z."xsd:string |
| http://purl.uniprot.org/citations/31371377 | http://purl.uniprot.org/core/author | "Otsuka Y."xsd:string |
| http://purl.uniprot.org/citations/31371377 | http://purl.uniprot.org/core/author | "Matsuda A."xsd:string |
| http://purl.uniprot.org/citations/31371377 | http://purl.uniprot.org/core/author | "Satoh T."xsd:string |
| http://purl.uniprot.org/citations/31371377 | http://purl.uniprot.org/core/author | "Satoh A.K."xsd:string |
| http://purl.uniprot.org/citations/31371377 | http://purl.uniprot.org/core/author | "Ogi S."xsd:string |
| http://purl.uniprot.org/citations/31371377 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31371377 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/31371377 | http://purl.uniprot.org/core/pages | "dev169292"xsd:string |
| http://purl.uniprot.org/citations/31371377 | http://purl.uniprot.org/core/title | "Syndapin constricts microvillar necks to form a united rhabdomere in Drosophila photoreceptors."xsd:string |
| http://purl.uniprot.org/citations/31371377 | http://purl.uniprot.org/core/volume | "146"xsd:string |
| http://purl.uniprot.org/citations/31371377 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31371377 |
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