| http://purl.uniprot.org/citations/31376136 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31376136 | http://www.w3.org/2000/01/rdf-schema#comment | "Ischemia and hypoxia are common pathophysiological characteristics in cardiovascular diseases. c-Jun expression could be induced by extra- or intracellular stimuli and plays a pivotal role in regulating cell survival in response to the stress. However, previous studies of c-Jun in cell proliferation and apoptosis showed conflicting results. In the present study, we demonstrated that the expression of c-Jun was induced by hypoxia in H9c2 cells. Loss of function of c-Jun was investigated by CCK-8, LDH, and TUNEL assays in low oxygen (1% O2) conditions. We revealed that c-Jun could promote cell survival and inhibit cell apoptosis under hypoxia. Knockdown of c-Jun also promoted the expression of apoptosis-related proteins under hypoxia, such as cleaved caspase-3, cleaved caspase-9, Bax, and Bim. Furthermore, we demonstrated that the knockdown of c-Jun inhibited the PTEN/Akt signaling pathway under hypoxia. Our findings suggested that c-Jun protected H9c2 cells from apoptosis and promoted the survival of H9c2 cells under hypoxia via PTEN/Akt signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/31376136 | http://purl.org/dc/terms/identifier | "doi:10.1007/s13105-019-00695-3"xsd:string |
| http://purl.uniprot.org/citations/31376136 | http://purl.uniprot.org/core/author | "He S."xsd:string |
| http://purl.uniprot.org/citations/31376136 | http://purl.uniprot.org/core/author | "Jiang Y."xsd:string |
| http://purl.uniprot.org/citations/31376136 | http://purl.uniprot.org/core/author | "Gao F."xsd:string |
| http://purl.uniprot.org/citations/31376136 | http://purl.uniprot.org/core/author | "Luo G."xsd:string |
| http://purl.uniprot.org/citations/31376136 | http://purl.uniprot.org/core/author | "Xiao Y."xsd:string |
| http://purl.uniprot.org/citations/31376136 | http://purl.uniprot.org/core/author | "Wu F."xsd:string |
| http://purl.uniprot.org/citations/31376136 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31376136 | http://purl.uniprot.org/core/name | "J Physiol Biochem"xsd:string |
| http://purl.uniprot.org/citations/31376136 | http://purl.uniprot.org/core/pages | "433-441"xsd:string |
| http://purl.uniprot.org/citations/31376136 | http://purl.uniprot.org/core/title | "c-Jun promotes the survival of H9c2 cells under hypoxia via PTEN/Akt signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/31376136 | http://purl.uniprot.org/core/volume | "75"xsd:string |
| http://purl.uniprot.org/citations/31376136 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31376136 |
| http://purl.uniprot.org/citations/31376136 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31376136 |
| http://purl.uniprot.org/uniprot/#_A6JRH4-mappedCitation-31376136 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31376136 |
| http://purl.uniprot.org/uniprot/#_P17325-mappedCitation-31376136 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31376136 |
| http://purl.uniprot.org/uniprot/A6JRH4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31376136 |
| http://purl.uniprot.org/uniprot/P17325 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31376136 |