| http://purl.uniprot.org/citations/31376935 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31376935 | http://www.w3.org/2000/01/rdf-schema#comment | "Dexamethasone (DEX) induces significant cytotoxicity to human osteoblasts. cPWWP2A is recently-indentified novel circular RNA (circRNA), acting as an endogenous sponge of microRNA-579 (miR-579). The present study tested the expression and potential functions of the cPWWP2A-miR-579 axis in DEX-treated osteoblasts. We show that cPWWP2A is downregulated in the necrotic femoral head tissues of DEX-taking human patients as well as in DEX-treated human osteoblasts. In OB-6 osteoblastic cells and primary human osteoblasts ectopic overexpression of cPWWP2A potently inhibited DEX-induced miR-579 accumulation, cell death, apoptosis and programmed necrosis. Silencing miR-579, by targeted siRNAs, also attenuated DEX-induced cytotoxicity in human osteoblasts. Significantly, mimicking DEX-induced actions, cPWWP2A silencing or forced miR-579 overexpression induced significant cytotoxicity in human osteoblasts. Further analyses demonstrated that miR-579's targets, including SIRT1 and PDK1 (phosphoinositide-dependent protein kinase 1), were downregulated in DEX-treated osteoblasts. Their levels were decreased as well in the necrotic femoral head tissues of DEX-taking human patients. Taken together we show that dysregulation of the cPWWP2A-miR-579 axis is involved in DEX-induced cytotoxicity in human osteoblasts."xsd:string |
| http://purl.uniprot.org/citations/31376935 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2019.07.095"xsd:string |
| http://purl.uniprot.org/citations/31376935 | http://purl.uniprot.org/core/author | "Chen J."xsd:string |
| http://purl.uniprot.org/citations/31376935 | http://purl.uniprot.org/core/author | "Cui Z."xsd:string |
| http://purl.uniprot.org/citations/31376935 | http://purl.uniprot.org/core/author | "Liu W."xsd:string |
| http://purl.uniprot.org/citations/31376935 | http://purl.uniprot.org/core/author | "Sun Y."xsd:string |
| http://purl.uniprot.org/citations/31376935 | http://purl.uniprot.org/core/author | "Deng H."xsd:string |
| http://purl.uniprot.org/citations/31376935 | http://purl.uniprot.org/core/author | "Hong H."xsd:string |
| http://purl.uniprot.org/citations/31376935 | http://purl.uniprot.org/core/author | "Yuan K."xsd:string |
| http://purl.uniprot.org/citations/31376935 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31376935 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/31376935 | http://purl.uniprot.org/core/pages | "491-498"xsd:string |
| http://purl.uniprot.org/citations/31376935 | http://purl.uniprot.org/core/title | "Dysregulation of cPWWP2A-miR-579 axis mediates dexamethasone-induced cytotoxicity in human osteoblasts."xsd:string |
| http://purl.uniprot.org/citations/31376935 | http://purl.uniprot.org/core/volume | "517"xsd:string |
| http://purl.uniprot.org/citations/31376935 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31376935 |
| http://purl.uniprot.org/citations/31376935 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31376935 |
| http://purl.uniprot.org/uniprot/#_Q7Z4D8-mappedCitation-31376935 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31376935 |
| http://purl.uniprot.org/uniprot/#_Q96N64-mappedCitation-31376935 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31376935 |
| http://purl.uniprot.org/uniprot/Q96N64 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31376935 |
| http://purl.uniprot.org/uniprot/Q7Z4D8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31376935 |