| http://purl.uniprot.org/citations/3138114 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/3138114 | http://www.w3.org/2000/01/rdf-schema#comment | "The gene mutation in the mouse, 'arrested development of righting response', adr, causes a defect of chloride conductance of the muscle fibre membrane leading to the symptoms of myotonia [Mehrke, G., Brinkmeier, H. and Jockusch, H. (1988) Muscle & Nerve 11, 440-446]. In fast muscle, the myotonic phenotype is accompanied by a drastic reduction of the Ca2+-binding protein, parvalbumin. Messenger RNA levels in organs of myotonic (ADR) mice were analysed. In fast muscles of the mutant, in-vitro-translatable parvalbumin mRNA was strongly reduced, whereas the mRNA for the slow-muscle-specific protein, p19/6.8, was increased. In contrast, the parvalbumin mRNA in the cerebellum was not affected by the adr mutation. A reduction of the two parvalbumin mRNA species (700 and 1100 nucleotides) in ADR fast muscle and unaltered parvalbumin mRNA levels in mutant cerebella were demonstrated by cDNA/mRNA hybridisation, using a rat parvalbumin cDNA as a probe. The mRNA level for another Ca2+-binding protein, calmodulin, was low in muscle and high in the central nervous system but was unaffected by the mutation. When adr/adr mice were fed a diet containing the membrane-stabilising drug, tocainide, the levels in muscle of the mRNAs for parvalbumin and p19/6.8 were partially normalised."xsd:string |
| http://purl.uniprot.org/citations/3138114 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1432-1033.1988.tb14262.x"xsd:string |
| http://purl.uniprot.org/citations/3138114 | http://purl.uniprot.org/core/author | "Schoffl F."xsd:string |
| http://purl.uniprot.org/citations/3138114 | http://purl.uniprot.org/core/author | "Berchtold M.W."xsd:string |
| http://purl.uniprot.org/citations/3138114 | http://purl.uniprot.org/core/author | "Jockusch H."xsd:string |
| http://purl.uniprot.org/citations/3138114 | http://purl.uniprot.org/core/author | "Kluxen F.W."xsd:string |
| http://purl.uniprot.org/citations/3138114 | http://purl.uniprot.org/core/date | "1988"xsd:gYear |
| http://purl.uniprot.org/citations/3138114 | http://purl.uniprot.org/core/name | "Eur J Biochem"xsd:string |
| http://purl.uniprot.org/citations/3138114 | http://purl.uniprot.org/core/pages | "153-158"xsd:string |
| http://purl.uniprot.org/citations/3138114 | http://purl.uniprot.org/core/title | "Opposite regulation of the mRNAs for parvalbumin and p19/6.8 in myotonic mouse muscle."xsd:string |
| http://purl.uniprot.org/citations/3138114 | http://purl.uniprot.org/core/volume | "176"xsd:string |
| http://purl.uniprot.org/citations/3138114 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/3138114 |
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| http://purl.uniprot.org/uniprot/#_A0A5F8MPY7-mappedCitation-3138114 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/3138114 |
| http://purl.uniprot.org/uniprot/#_F7C9S1-mappedCitation-3138114 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/3138114 |
| http://purl.uniprot.org/uniprot/#_E9Q2N3-mappedCitation-3138114 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/3138114 |
| http://purl.uniprot.org/uniprot/#_F6VSA8-mappedCitation-3138114 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/3138114 |
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| http://purl.uniprot.org/uniprot/#_F6QL23-mappedCitation-3138114 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/3138114 |
| http://purl.uniprot.org/uniprot/#_F7A9J6-mappedCitation-3138114 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/3138114 |
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| http://purl.uniprot.org/uniprot/#_Q3TTA5-mappedCitation-3138114 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/3138114 |