| http://purl.uniprot.org/citations/31381180 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31381180 | http://www.w3.org/2000/01/rdf-schema#comment | "Exercise stimulates cellular and physiological adaptations that are associated with widespread health benefits. To uncover conserved protein phosphorylation events underlying this adaptive response, we performed mass spectrometry-based phosphoproteomic analyses of skeletal muscle from two widely used rodent models: treadmill running in mice and in situ muscle contraction in rats. We overlaid these phosphoproteomic signatures with cycling in humans to identify common cross-species phosphosite responses, as well as unique model-specific regulation. We identified > 22,000 phosphosites, revealing orthologous protein phosphorylation and overlapping signaling pathways regulated by exercise. This included two conserved phosphosites on stromal interaction molecule 1 (STIM1), which we validate as AMPK substrates. Furthermore, we demonstrate that AMPK-mediated phosphorylation of STIM1 negatively regulates store-operated calcium entry, and this is beneficial for exercise in Drosophila. This integrated cross-species resource of exercise-regulated signaling in human, mouse, and rat skeletal muscle has uncovered conserved networks and unraveled crosstalk between AMPK and intracellular calcium flux."xsd:string |
| http://purl.uniprot.org/citations/31381180 | http://purl.org/dc/terms/identifier | "doi:10.15252/embj.2019102578"xsd:string |
| http://purl.uniprot.org/citations/31381180 | http://purl.uniprot.org/core/author | "Chaudhuri R."xsd:string |
| http://purl.uniprot.org/citations/31381180 | http://purl.uniprot.org/core/author | "James D.E."xsd:string |
| http://purl.uniprot.org/citations/31381180 | http://purl.uniprot.org/core/author | "Francis D."xsd:string |
| http://purl.uniprot.org/citations/31381180 | http://purl.uniprot.org/core/author | "Ling N.X."xsd:string |
| http://purl.uniprot.org/citations/31381180 | http://purl.uniprot.org/core/author | "Lynch G.S."xsd:string |
| http://purl.uniprot.org/citations/31381180 | http://purl.uniprot.org/core/author | "Oakhill J.S."xsd:string |
| http://purl.uniprot.org/citations/31381180 | http://purl.uniprot.org/core/author | "Richter E.A."xsd:string |
| http://purl.uniprot.org/citations/31381180 | http://purl.uniprot.org/core/author | "Parker B.L."xsd:string |
| http://purl.uniprot.org/citations/31381180 | http://purl.uniprot.org/core/author | "Cooke K.C."xsd:string |
| http://purl.uniprot.org/citations/31381180 | http://purl.uniprot.org/core/author | "Nelson M.E."xsd:string |
| http://purl.uniprot.org/citations/31381180 | http://purl.uniprot.org/core/author | "Stockli J."xsd:string |
| http://purl.uniprot.org/citations/31381180 | http://purl.uniprot.org/core/author | "Burchfield J.G."xsd:string |
| http://purl.uniprot.org/citations/31381180 | http://purl.uniprot.org/core/author | "Sylow L."xsd:string |
| http://purl.uniprot.org/citations/31381180 | http://purl.uniprot.org/core/author | "Naim T."xsd:string |
| http://purl.uniprot.org/citations/31381180 | http://purl.uniprot.org/core/author | "Hoffman N.J."xsd:string |
| http://purl.uniprot.org/citations/31381180 | http://purl.uniprot.org/core/author | "Needham E.J."xsd:string |
| http://purl.uniprot.org/citations/31381180 | http://purl.uniprot.org/core/author | "Norris D.M."xsd:string |
| http://purl.uniprot.org/citations/31381180 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31381180 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/31381180 | http://purl.uniprot.org/core/pages | "e102578"xsd:string |
| http://purl.uniprot.org/citations/31381180 | http://purl.uniprot.org/core/title | "Phosphoproteomics reveals conserved exercise-stimulated signaling and AMPK regulation of store-operated calcium entry."xsd:string |
| http://purl.uniprot.org/citations/31381180 | http://purl.uniprot.org/core/volume | "38"xsd:string |