| http://purl.uniprot.org/citations/31386623 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31386623 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31386623 | http://www.w3.org/2000/01/rdf-schema#comment | "Cellular differentiation requires both activation of target cell transcriptional programs and repression of non-target cell programs. The Myt1 family of zinc finger transcription factors contributes to fibroblast to neuron reprogramming in vitro. Here, we show that ztf-11 (Zinc-finger Transcription Factor-11), the sole Caenorhabditis elegans Myt1 homolog, is required for neurogenesis in multiple neuronal lineages from previously differentiated epithelial cells, including a neuron generated by a developmental epithelial-to-neuronal transdifferentiation event. ztf-11 is exclusively expressed in all neuronal precursors with remarkable specificity at single-cell resolution. Loss of ztf-11 leads to upregulation of non-neuronal genes and reduced neurogenesis. Ectopic expression of ztf-11 in epidermal lineages is sufficient to produce additional neurons. ZTF-11 functions together with the MuvB corepressor complex to suppress the activation of non-neuronal genes in neurons. These results dovetail with the ability of Myt1l (Myt1-like) to drive neuronal transdifferentiation in vitro in vertebrate systems. Together, we identified an evolutionarily conserved mechanism to specify neuronal cell fate by repressing non-neuronal genes."xsd:string |
| http://purl.uniprot.org/citations/31386623 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.46703"xsd:string |
| http://purl.uniprot.org/citations/31386623 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.46703"xsd:string |
| http://purl.uniprot.org/citations/31386623 | http://purl.uniprot.org/core/author | "Chen A."xsd:string |
| http://purl.uniprot.org/citations/31386623 | http://purl.uniprot.org/core/author | "Chen A."xsd:string |
| http://purl.uniprot.org/citations/31386623 | http://purl.uniprot.org/core/author | "Bao Z."xsd:string |
| http://purl.uniprot.org/citations/31386623 | http://purl.uniprot.org/core/author | "Bao Z."xsd:string |
| http://purl.uniprot.org/citations/31386623 | http://purl.uniprot.org/core/author | "Lee J."xsd:string |
| http://purl.uniprot.org/citations/31386623 | http://purl.uniprot.org/core/author | "Lee J."xsd:string |
| http://purl.uniprot.org/citations/31386623 | http://purl.uniprot.org/core/author | "Shen K."xsd:string |
| http://purl.uniprot.org/citations/31386623 | http://purl.uniprot.org/core/author | "Shen K."xsd:string |
| http://purl.uniprot.org/citations/31386623 | http://purl.uniprot.org/core/author | "Shen A."xsd:string |
| http://purl.uniprot.org/citations/31386623 | http://purl.uniprot.org/core/author | "Shen A."xsd:string |
| http://purl.uniprot.org/citations/31386623 | http://purl.uniprot.org/core/author | "Stewart E.V."xsd:string |
| http://purl.uniprot.org/citations/31386623 | http://purl.uniprot.org/core/author | "Stewart E.V."xsd:string |
| http://purl.uniprot.org/citations/31386623 | http://purl.uniprot.org/core/author | "Taylor C.A."xsd:string |
| http://purl.uniprot.org/citations/31386623 | http://purl.uniprot.org/core/author | "Taylor C.A."xsd:string |
| http://purl.uniprot.org/citations/31386623 | http://purl.uniprot.org/core/author | "Xiang Y.K."xsd:string |
| http://purl.uniprot.org/citations/31386623 | http://purl.uniprot.org/core/author | "Xiang Y.K."xsd:string |
| http://purl.uniprot.org/citations/31386623 | http://purl.uniprot.org/core/author | "Barnes K.M."xsd:string |
| http://purl.uniprot.org/citations/31386623 | http://purl.uniprot.org/core/author | "Barnes K.M."xsd:string |
| http://purl.uniprot.org/citations/31386623 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31386623 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |