| http://purl.uniprot.org/citations/31387916 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31387916 | http://www.w3.org/2000/01/rdf-schema#comment | "The microbiota regulate hematopoiesis in the bone marrow (BM); however, the detailed mechanisms remain largely unknown. In this study, we explored how microbiota-derived molecules (MDMs) were transferred to the BM and sensed by the local immune cells to control hematopoiesis under steady-state conditions. We reveal that MDMs, including bacterial DNA (bDNA), reach the BM via systemic blood circulation and are captured by CX3CR1+ mononuclear cells (MNCs). CX3CR1+ MNCs sense MDMs via endolysosomal Toll-like receptors (TLRs) to produce inflammatory cytokines, which control the basal expansion of hematopoietic progenitors, but not hematopoietic stem cells, and their differentiation potential toward myeloid lineages. CX3CR1+ MNCs colocate with hematopoietic progenitors at the perivascular region, and the depletion of CX3CR1+ MNCs impedes bDNA influx into the BM. Moreover, the abrogation of TLR pathways in CX3CR1+ MNCs abolished the microbiota effect on hematopoiesis. These studies demonstrate that systemic MDMs control BM hematopoiesis by producing CX3CR1+ MNC-mediated cytokines in the steady-state."xsd:string |
| http://purl.uniprot.org/citations/31387916 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood.2019000495"xsd:string |
| http://purl.uniprot.org/citations/31387916 | http://purl.uniprot.org/core/author | "Lee S."xsd:string |
| http://purl.uniprot.org/citations/31387916 | http://purl.uniprot.org/core/author | "Kim H."xsd:string |
| http://purl.uniprot.org/citations/31387916 | http://purl.uniprot.org/core/author | "Kim K.H."xsd:string |
| http://purl.uniprot.org/citations/31387916 | http://purl.uniprot.org/core/author | "Kim K.S."xsd:string |
| http://purl.uniprot.org/citations/31387916 | http://purl.uniprot.org/core/author | "Park Y."xsd:string |
| http://purl.uniprot.org/citations/31387916 | http://purl.uniprot.org/core/author | "Lee S.W."xsd:string |
| http://purl.uniprot.org/citations/31387916 | http://purl.uniprot.org/core/author | "Kim Y.M."xsd:string |
| http://purl.uniprot.org/citations/31387916 | http://purl.uniprot.org/core/author | "Kwon O."xsd:string |
| http://purl.uniprot.org/citations/31387916 | http://purl.uniprot.org/core/author | "Lee S.'"xsd:string |
| http://purl.uniprot.org/citations/31387916 | http://purl.uniprot.org/core/author | "Sung Y.C."xsd:string |
| http://purl.uniprot.org/citations/31387916 | http://purl.uniprot.org/core/author | "Kim Y.M.'"xsd:string |
| http://purl.uniprot.org/citations/31387916 | http://purl.uniprot.org/core/author | "Im S.H."xsd:string |
| http://purl.uniprot.org/citations/31387916 | http://purl.uniprot.org/core/author | "You G."xsd:string |
| http://purl.uniprot.org/citations/31387916 | http://purl.uniprot.org/core/author | "Surh C.D."xsd:string |
| http://purl.uniprot.org/citations/31387916 | http://purl.uniprot.org/core/author | "Le V.H."xsd:string |
| http://purl.uniprot.org/citations/31387916 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31387916 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/31387916 | http://purl.uniprot.org/core/pages | "1312-1322"xsd:string |
| http://purl.uniprot.org/citations/31387916 | http://purl.uniprot.org/core/title | "Bone marrow CX3CR1+ mononuclear cells relay a systemic microbiota signal to control hematopoietic progenitors in mice."xsd:string |
| http://purl.uniprot.org/citations/31387916 | http://purl.uniprot.org/core/volume | "134"xsd:string |
| http://purl.uniprot.org/citations/31387916 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31387916 |
| http://purl.uniprot.org/citations/31387916 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31387916 |