| http://purl.uniprot.org/citations/31390091 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31390091 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31390091 | http://www.w3.org/2000/01/rdf-schema#comment | "RIG-I-MAVS antiviral signaling represents an important pathway to stimulate interferon production and confer innate immunity to the host. Upon binding to viral RNA and Riplet-mediated polyubiquitination, RIG-I promotes prion-like aggregation and activation of MAVS. MAVS subsequently induces interferon production by activating two signaling pathways mediated by TBK1-IRF3 and IKK-NF-κB respectively. However, the mechanism underlying the activation of MAVS downstream pathways remains elusive. Here, we demonstrated that activation of TBK1-IRF3 by MAVS-Region III depends on its multimerization state and identified TRAF3IP3 as a critical regulator for the downstream signaling. In response to virus infection, TRAF3IP3 is accumulated on mitochondria and thereby facilitates the recruitment of TRAF3 to MAVS for TBK1-IRF3 activation. Traf3ip3-deficient mice demonstrated a severely compromised potential to induce interferon production and were vulnerable to RNA virus infection. Our findings uncover that TRAF3IP3 is an important regulator for RIG-I-MAVS signaling, which bridges MAVS and TRAF3 for an effective antiviral innate immune response."xsd:string |
| http://purl.uniprot.org/citations/31390091 | http://purl.org/dc/terms/identifier | "doi:10.15252/embj.2019102075"xsd:string |
| http://purl.uniprot.org/citations/31390091 | http://purl.org/dc/terms/identifier | "doi:10.15252/embj.2019102075"xsd:string |
| http://purl.uniprot.org/citations/31390091 | http://purl.uniprot.org/core/author | "Chen S."xsd:string |
| http://purl.uniprot.org/citations/31390091 | http://purl.uniprot.org/core/author | "Chen S."xsd:string |
| http://purl.uniprot.org/citations/31390091 | http://purl.uniprot.org/core/author | "Cai Y."xsd:string |
| http://purl.uniprot.org/citations/31390091 | http://purl.uniprot.org/core/author | "Cai Y."xsd:string |
| http://purl.uniprot.org/citations/31390091 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/31390091 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/31390091 | http://purl.uniprot.org/core/author | "Liang X."xsd:string |
| http://purl.uniprot.org/citations/31390091 | http://purl.uniprot.org/core/author | "Liang X."xsd:string |
| http://purl.uniprot.org/citations/31390091 | http://purl.uniprot.org/core/author | "Qi S."xsd:string |
| http://purl.uniprot.org/citations/31390091 | http://purl.uniprot.org/core/author | "Qi S."xsd:string |
| http://purl.uniprot.org/citations/31390091 | http://purl.uniprot.org/core/author | "Wang C."xsd:string |
| http://purl.uniprot.org/citations/31390091 | http://purl.uniprot.org/core/author | "Wang C."xsd:string |
| http://purl.uniprot.org/citations/31390091 | http://purl.uniprot.org/core/author | "Zhang R."xsd:string |
| http://purl.uniprot.org/citations/31390091 | http://purl.uniprot.org/core/author | "Zhang R."xsd:string |
| http://purl.uniprot.org/citations/31390091 | http://purl.uniprot.org/core/author | "Zhu W."xsd:string |
| http://purl.uniprot.org/citations/31390091 | http://purl.uniprot.org/core/author | "Zhu W."xsd:string |
| http://purl.uniprot.org/citations/31390091 | http://purl.uniprot.org/core/author | "Hou F."xsd:string |
| http://purl.uniprot.org/citations/31390091 | http://purl.uniprot.org/core/author | "Hou F."xsd:string |
| http://purl.uniprot.org/citations/31390091 | http://purl.uniprot.org/core/author | "Qi N."xsd:string |
| http://purl.uniprot.org/citations/31390091 | http://purl.uniprot.org/core/author | "Qi N."xsd:string |