| http://purl.uniprot.org/citations/31396219 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31396219 | http://www.w3.org/2000/01/rdf-schema#comment | "IL-1 family member IL-33 exerts a variety of immune activating and regulating properties and has recently been proposed as a prognostic biomarker for cancer diseases, although its precise role in tumor immunity is unclear. Here we analyzed in vitro conditions influencing the function of IL-33 as an alarmin and a co-factor for the activity of cytotoxic CD8+ T cells in order to explain the widely discussed promiscuous behavior of IL-33 in vivo. Circulating IL-33 detected in the serum of healthy human volunteers was biologically inactive. Additionally, bioactivity of exogenous recombinant IL-33 was significantly reduced in plasma, suggesting local effects of IL-33, and inactivation in blood. Limited availability of nutrients in tissue causes necrosis and thus favors release of IL-33, which-as described before-leads to a locally high expression of the cytokine. The harsh conditions however influence T cell fitness and their responsiveness to stimuli. Nutrient deprivation and pharmacological inhibition of mTOR mediated a distinctive phenotype characterized by expression of IL-33 receptor ST2L on isolated CD8+ T cells, downregulation of CD8, a transitional CD45RAlowROlow phenotype and high expression of secondary lymphoid organ chemokine receptor CCR7. Under nutrient deprivation, IL-33 inhibited an IL-12 induced increase in granzyme B protein expression and increased expression of GATA3 and FOXP3 mRNA. IL-33 enhanced the TCR-dependent activation of CD8+ T cells and co-stimulated the IL-12/TCR-dependent expression of IFNγ. Respectively, GATA3 and FOXP3 mRNA were not regulated during TCR-dependent activation. TCR-dependent stimulation of PBMC, but not LPS, initiated mRNA expression of soluble IL-33 decoy receptor sST2, a control mechanism limiting IL-33 bioactivity to avoid uncontrolled inflammation. Our findings contribute to the understanding of the compartment-specific activity of IL-33. Furthermore, we newly describe conditions, which promote an IL-33-dependent induction of pro- or anti-inflammatory activity in CD8+ T cells during nutrient deprivation."xsd:string |
| http://purl.uniprot.org/citations/31396219 | http://purl.org/dc/terms/identifier | "doi:10.3389/fimmu.2019.01698"xsd:string |
| http://purl.uniprot.org/citations/31396219 | http://purl.uniprot.org/core/author | "Ernst A."xsd:string |
| http://purl.uniprot.org/citations/31396219 | http://purl.uniprot.org/core/author | "Radeke H.H."xsd:string |
| http://purl.uniprot.org/citations/31396219 | http://purl.uniprot.org/core/author | "Pfeilschifter J.M."xsd:string |
| http://purl.uniprot.org/citations/31396219 | http://purl.uniprot.org/core/author | "Putyrski M."xsd:string |
| http://purl.uniprot.org/citations/31396219 | http://purl.uniprot.org/core/author | "Schmidt K.G."xsd:string |
| http://purl.uniprot.org/citations/31396219 | http://purl.uniprot.org/core/author | "Huhn M."xsd:string |
| http://purl.uniprot.org/citations/31396219 | http://purl.uniprot.org/core/author | "Dreis C."xsd:string |
| http://purl.uniprot.org/citations/31396219 | http://purl.uniprot.org/core/author | "Ottenlinger F.M."xsd:string |
| http://purl.uniprot.org/citations/31396219 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31396219 | http://purl.uniprot.org/core/name | "Front Immunol"xsd:string |
| http://purl.uniprot.org/citations/31396219 | http://purl.uniprot.org/core/pages | "1698"xsd:string |
| http://purl.uniprot.org/citations/31396219 | http://purl.uniprot.org/core/title | "Tissue Cytokine IL-33 Modulates the Cytotoxic CD8 T Lymphocyte Activity During Nutrient Deprivation by Regulation of Lineage-Specific Differentiation Programs."xsd:string |
| http://purl.uniprot.org/citations/31396219 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/31396219 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31396219 |
| http://purl.uniprot.org/citations/31396219 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31396219 |
| http://purl.uniprot.org/uniprot/#_A0A1I9RI50-mappedCitation-31396219 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31396219 |
| http://purl.uniprot.org/uniprot/#_A0A1I9RI51-mappedCitation-31396219 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31396219 |
| http://purl.uniprot.org/uniprot/#_O95760-mappedCitation-31396219 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31396219 |
| http://purl.uniprot.org/uniprot/A0A1I9RI50 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31396219 |
| http://purl.uniprot.org/uniprot/O95760 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31396219 |
| http://purl.uniprot.org/uniprot/A0A1I9RI51 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31396219 |