| http://purl.uniprot.org/citations/31411918 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31411918 | http://www.w3.org/2000/01/rdf-schema#comment | "Keloid, characterized by exuberant collagen deposition and invasive growth beyond original wound margins, results from abnormal wound healing. A recent microarray analysis identified homeobox (HOX) A11 antisense (HOXA11-AS) as a keloid-specific long non-coding RNA, although its potential role in keloid formation remains elusive. In this study, hematoxylin-eosin, Masson, and immunohistochemical staining of type I collagen (ColI) revealed abnormal arrangement and hyperplasia of fibers in keloid tissues along with increased ColI level. qRT-PCR and Western blot showed that HOXA11-AS and ColI were significantly upregulated, while miR-124-3p was decreased in both keloid tissues and human keloid fibroblasts (HKFs). Knockdown of HOXA11-AS inhibited cell proliferation (by CCK-8 and immunofluorescence staining of Ki67) and cell migration (by wound healing and transwell assays). Mechanistic experiments verified that HOXA11-AS acted as a sponge of micro-RNA (miR)-124-3p and Smad5 was a target of miR-124-3p. miR-124-3p sufficiently reversed the regulatory effects of HOXA11-AS, and Smad5 was involved in miR-124-3p-mediated biological functions. Furthermore, HOXA11-AS induced ColI synthesis via sponging miR-124-3p-mediated Smad5 signaling, thus promoting keloid formation. Overall, our study implied that HOXA11-AS induces ColI synthesis to promoted keloid formation via sponging miR-124-3p-mediated Smad5 signaling, which might offer a novel target for developing the therapy of keloid formation."xsd:string |
| http://purl.uniprot.org/citations/31411918 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajpcell.00319.2018"xsd:string |
| http://purl.uniprot.org/citations/31411918 | http://purl.uniprot.org/core/author | "Jin J."xsd:string |
| http://purl.uniprot.org/citations/31411918 | http://purl.uniprot.org/core/author | "Jia Z.H."xsd:string |
| http://purl.uniprot.org/citations/31411918 | http://purl.uniprot.org/core/author | "Luo X.H."xsd:string |
| http://purl.uniprot.org/citations/31411918 | http://purl.uniprot.org/core/author | "Zhai H.F."xsd:string |
| http://purl.uniprot.org/citations/31411918 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31411918 | http://purl.uniprot.org/core/name | "Am J Physiol Cell Physiol"xsd:string |
| http://purl.uniprot.org/citations/31411918 | http://purl.uniprot.org/core/pages | "C1001-C1010"xsd:string |
| http://purl.uniprot.org/citations/31411918 | http://purl.uniprot.org/core/title | "Long non-coding RNA HOXA11-AS induces type I collagen synthesis to stimulate keloid formation via sponging miR-124-3p and activation of Smad5 signaling."xsd:string |
| http://purl.uniprot.org/citations/31411918 | http://purl.uniprot.org/core/volume | "317"xsd:string |
| http://purl.uniprot.org/citations/31411918 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31411918 |
| http://purl.uniprot.org/citations/31411918 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31411918 |
| http://purl.uniprot.org/uniprot/#_B2R9U5-mappedCitation-31411918 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31411918 |
| http://purl.uniprot.org/uniprot/#_P31270-mappedCitation-31411918 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31411918 |
| http://purl.uniprot.org/uniprot/P31270 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31411918 |
| http://purl.uniprot.org/uniprot/B2R9U5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31411918 |