DESCRIBE <http://purl.uniprot.org/citations/31412816>

Subject	Predicate	Object
http://purl.uniprot.org/citations/31412816	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/31412816	http://www.w3.org/2000/01/rdf-schema#comment	" Background Endometrial cancer is the most common gynecological cancer. G-protein coupled receptor 64 (GPR64) belongs to a family of adhesion GPCRs and plays an important role in male fertility. However, the function of GPR64 has not been studied in endometrial cancer. Our objective is to investigate the role of GPR64 in endometrial cancer. Methods We examined the levels of GPR64 in human endometrioid endometrial carcinoma by immunohistochemistry analysis. To determine a tumor suppressor role of GPR64 in endometrial cancer, we used a siRNA loss of function approach in human endometrial adenocarcinoma cell lines. Results GPR64 levels were remarkably lower in 10 of 21 (47.62%) of endometrial carcinoma samples compared to control. Depletion of GPR64 by siRNA transfection revealed an increase of colony formation ability, cell proliferation, cell migration, and invasion activity in Ishikawa and HEC1A cells. The expression of Connexin 43 (Cx43), a member of the large family of gap junction proteins, was reduced through activation of AMP-activated protein kinase (AMPK) in Ishikawa cells with GPR64-deficicy. Conclusions These results suggest that GPR64 plays an important tumor suppressor role in endometrial cancer."xsd:string
http://purl.uniprot.org/citations/31412816	http://purl.org/dc/terms/identifier	"doi:10.1186/s12885-019-5998-1"xsd:string
http://purl.uniprot.org/citations/31412816	http://purl.uniprot.org/core/author	"Lim J.M."xsd:string
http://purl.uniprot.org/citations/31412816	http://purl.uniprot.org/core/author	"Ahn J.Y."xsd:string
http://purl.uniprot.org/citations/31412816	http://purl.uniprot.org/core/author	"Kim Y.I."xsd:string
http://purl.uniprot.org/citations/31412816	http://purl.uniprot.org/core/author	"Yoo J.Y."xsd:string
http://purl.uniprot.org/citations/31412816	http://purl.uniprot.org/core/author	"Kim T.H."xsd:string
http://purl.uniprot.org/citations/31412816	http://purl.uniprot.org/core/author	"Jeong J.W."xsd:string
http://purl.uniprot.org/citations/31412816	http://purl.uniprot.org/core/author	"Broaddus R.R."xsd:string
http://purl.uniprot.org/citations/31412816	http://purl.uniprot.org/core/author	"Ahn J.I."xsd:string
http://purl.uniprot.org/citations/31412816	http://purl.uniprot.org/core/date	"2019"xsd:gYear
http://purl.uniprot.org/citations/31412816	http://purl.uniprot.org/core/name	"BMC Cancer"xsd:string
http://purl.uniprot.org/citations/31412816	http://purl.uniprot.org/core/pages	"810"xsd:string
http://purl.uniprot.org/citations/31412816	http://purl.uniprot.org/core/title	"G-protein coupled receptor 64 (GPR64) acts as a tumor suppressor in endometrial cancer."xsd:string
http://purl.uniprot.org/citations/31412816	http://purl.uniprot.org/core/volume	"19"xsd:string
http://purl.uniprot.org/citations/31412816	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/31412816
http://purl.uniprot.org/citations/31412816	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/31412816
http://purl.uniprot.org/uniprot/#_A8K4P7-mappedCitation-31412816	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/31412816
http://purl.uniprot.org/uniprot/#_Q14CE1-mappedCitation-31412816	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/31412816
http://purl.uniprot.org/uniprot/#_Q499H0-mappedCitation-31412816	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/31412816
http://purl.uniprot.org/uniprot/#_Q8IZP9-mappedCitation-31412816	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/31412816
http://purl.uniprot.org/uniprot/#_Q8NF77-mappedCitation-31412816	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/31412816
http://purl.uniprot.org/uniprot/Q8IZP9	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/31412816
http://purl.uniprot.org/uniprot/Q8NF77	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/31412816