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http://purl.uniprot.org/citations/31425920http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
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Background

Rearrangements of RET are drivers of oncogenesis, traceable in different cancer types as papillary thyroid carcinoma (PTC), non-small cell lung cancer, colorectal or breast cancer. Anchored multiplex PCR based next-generation sequencing (NGS) can detect RET rearrangements involving previously unknown partner genes.

Methods

A sample of PTC underwent NGS, following detection of RET rearrangement by fluorescence in situ hybridization. Expression analysis of ANKRD26 and RET was performed for the tumor harboring ANKRD26-RET, for corresponding normal thyroid tissue and PTC tumors with representative genetic alterations (BRAFV600E, CCDC6-RET), complemented by a comparative search in the "UniProt" database.

Results

NGS analysis resulted in the discovery of the fusion ANKRD26-RET. ANKRD26 mRNA was expressed in all PTC tumors (ANKRD26-RET, BRAFV600E, CCDC6-RET) and in normal thyroid tissue, whereas RET mRNA was detected only in the tumors with RET rearrangement. On protein level, ANKRD26-RET combines the RET tyrosine kinase to ankyrin repeat and coiled-coil domains.

Conclusions

ANKRD26-RET is a novel rearrangement of the RET gene, associated with RET expression in thyroid tissue. The result is a fusion of the RET tyrosine kinase to prominent protein-protein interaction motifs. Further studies are required to investigate the influence of different RET rearrangements on metastasis and disease-free survival in PTC."xsd:string
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http://purl.uniprot.org/citations/31425920http://purl.uniprot.org/core/author"Lang H."xsd:string
http://purl.uniprot.org/citations/31425920http://purl.uniprot.org/core/author"Springer E."xsd:string
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http://purl.uniprot.org/citations/31425920http://purl.uniprot.org/core/author"Hartmann N."xsd:string
http://purl.uniprot.org/citations/31425920http://purl.uniprot.org/core/author"Rajalingam K."xsd:string
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http://purl.uniprot.org/citations/31425920http://purl.uniprot.org/core/author"Musholt T.J."xsd:string
http://purl.uniprot.org/citations/31425920http://purl.uniprot.org/core/author"Staubitz J.I."xsd:string
http://purl.uniprot.org/citations/31425920http://purl.uniprot.org/core/date"2019"xsd:gYear
http://purl.uniprot.org/citations/31425920http://purl.uniprot.org/core/name"Cancer Genet"xsd:string
http://purl.uniprot.org/citations/31425920http://purl.uniprot.org/core/pages"10-17"xsd:string
http://purl.uniprot.org/citations/31425920http://purl.uniprot.org/core/title"ANKRD26-RET - A novel gene fusion involving RET in papillary thyroid carcinoma."xsd:string
http://purl.uniprot.org/citations/31425920http://purl.uniprot.org/core/volume"238"xsd:string
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