| http://purl.uniprot.org/citations/31427534 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31427534 | http://www.w3.org/2000/01/rdf-schema#comment | "Translational control plays a key role in regulation of neuronal activity and behavior. Deletion of the translational repressor 4E-BP2 in mice alters excitatory and inhibitory synaptic functions, engendering autistic-like behaviors. The contribution of 4E-BP2-dependent translational control in excitatory and inhibitory neurons and astrocytic cells to these behaviors remains unknown. To investigate this, we generated cell-type-specific conditional 4E-BP2 knockout mice and tested them for the salient features of autism, including repetitive stereotyped behaviors (self-grooming and marble burying), sociability (3-chamber social and direct social interaction tests), and communication (ultrasonic vocalizations in pups). We found that deletion of 4E-BP2 in GABAergic inhibitory neurons, defined by Gad2, resulted in impairments in social interaction and vocal communication. In contrast, deletion of 4E-BP2 in forebrain glutamatergic excitatory neurons, defined by Camk2a, or in astrocytes, defined by Gfap, failed to cause autistic-like behavioral abnormalities. Taken together, we provide evidence for an inhibitory-cell-specific role of 4E-BP2 in engendering autism-related behaviors."xsd:string |
| http://purl.uniprot.org/citations/31427534 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1908126116"xsd:string |
| http://purl.uniprot.org/citations/31427534 | http://purl.uniprot.org/core/author | "Park J."xsd:string |
| http://purl.uniprot.org/citations/31427534 | http://purl.uniprot.org/core/author | "Khoutorsky A."xsd:string |
| http://purl.uniprot.org/citations/31427534 | http://purl.uniprot.org/core/author | "Sonenberg N."xsd:string |
| http://purl.uniprot.org/citations/31427534 | http://purl.uniprot.org/core/author | "Wiebe S."xsd:string |
| http://purl.uniprot.org/citations/31427534 | http://purl.uniprot.org/core/author | "Nagpal A."xsd:string |
| http://purl.uniprot.org/citations/31427534 | http://purl.uniprot.org/core/author | "Skalecka A."xsd:string |
| http://purl.uniprot.org/citations/31427534 | http://purl.uniprot.org/core/author | "Gantois I."xsd:string |
| http://purl.uniprot.org/citations/31427534 | http://purl.uniprot.org/core/author | "Truong V.T."xsd:string |
| http://purl.uniprot.org/citations/31427534 | http://purl.uniprot.org/core/author | "Gamache K."xsd:string |
| http://purl.uniprot.org/citations/31427534 | http://purl.uniprot.org/core/author | "He A.J."xsd:string |
| http://purl.uniprot.org/citations/31427534 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31427534 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/31427534 | http://purl.uniprot.org/core/pages | "18060-18067"xsd:string |
| http://purl.uniprot.org/citations/31427534 | http://purl.uniprot.org/core/title | "Inhibitory interneurons mediate autism-associated behaviors via 4E-BP2."xsd:string |
| http://purl.uniprot.org/citations/31427534 | http://purl.uniprot.org/core/volume | "116"xsd:string |
| http://purl.uniprot.org/citations/31427534 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31427534 |
| http://purl.uniprot.org/citations/31427534 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31427534 |
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| http://purl.uniprot.org/uniprot/#_P48320-mappedCitation-31427534 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31427534 |
| http://purl.uniprot.org/uniprot/#_Q548L4-mappedCitation-31427534 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31427534 |