| http://purl.uniprot.org/citations/31430272 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31430272 | http://www.w3.org/2000/01/rdf-schema#comment | "Zebrafish dorsal forerunner cells (DFCs) undergo vigorous proliferation during epiboly and then exit the cell cycle to generate Kupffer's vesicle (KV), a ciliated organ necessary for establishing left-right (L-R) asymmetry. DFC proliferation defects are often accompanied by impaired cilia elongation in KV, but the functional and molecular interaction between cell-cycle progression and cilia formation remains unknown. Here, we show that chemokine receptor Cxcr4a is required for L-R laterality by controlling DFC proliferation and KV ciliogenesis. Functional analysis revealed that Cxcr4a accelerates G1/S transition in DFCs and stabilizes forkhead box j1a (Foxj1a), a master regulator of motile cilia, by stimulating Cyclin D1 expression through extracellular regulated MAP kinase (ERK) 1/2 signaling. Mechanistically, Cyclin D1-cyclin-dependent kinase (CDK) 4/6 drives G1/S transition during DFC proliferation and phosphorylates Foxj1a, thereby disrupting its association with proteasome 26S subunit, non-ATPase 4b (Psmd4b), a 19S regulatory subunit. This prevents the ubiquitin (Ub)-independent proteasomal degradation of Foxj1a. Our study uncovers a role for Cxcr4 signaling in L-R patterning and provides fundamental insights into the molecular linkage between cell-cycle progression and ciliogenesis."xsd:string |
| http://purl.uniprot.org/citations/31430272 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pbio.3000203"xsd:string |
| http://purl.uniprot.org/citations/31430272 | http://purl.uniprot.org/core/author | "Cao Y."xsd:string |
| http://purl.uniprot.org/citations/31430272 | http://purl.uniprot.org/core/author | "Huang S."xsd:string |
| http://purl.uniprot.org/citations/31430272 | http://purl.uniprot.org/core/author | "Liu J."xsd:string |
| http://purl.uniprot.org/citations/31430272 | http://purl.uniprot.org/core/author | "Wang Q."xsd:string |
| http://purl.uniprot.org/citations/31430272 | http://purl.uniprot.org/core/author | "Yang L."xsd:string |
| http://purl.uniprot.org/citations/31430272 | http://purl.uniprot.org/core/author | "Zhu C."xsd:string |
| http://purl.uniprot.org/citations/31430272 | http://purl.uniprot.org/core/author | "Ning G."xsd:string |
| http://purl.uniprot.org/citations/31430272 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31430272 | http://purl.uniprot.org/core/name | "PLoS Biol"xsd:string |
| http://purl.uniprot.org/citations/31430272 | http://purl.uniprot.org/core/pages | "e3000203"xsd:string |
| http://purl.uniprot.org/citations/31430272 | http://purl.uniprot.org/core/title | "Chemokine signaling links cell-cycle progression and cilia formation for left-right symmetry breaking."xsd:string |
| http://purl.uniprot.org/citations/31430272 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/31430272 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31430272 |
| http://purl.uniprot.org/citations/31430272 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31430272 |
| http://purl.uniprot.org/uniprot/Q6V9B5#attribution-953B269EDB480E83442126FC5641A2F2 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/31430272 |
| http://purl.uniprot.org/uniprot/Q7ZU02#attribution-953B269EDB480E83442126FC5641A2F2 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/31430272 |
| http://purl.uniprot.org/uniprot/#_Q7ZU02-mappedCitation-31430272 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31430272 |
| http://purl.uniprot.org/uniprot/#_Q6V9B5-mappedCitation-31430272 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31430272 |
| http://purl.uniprot.org/uniprot/Q6V9B5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31430272 |
| http://purl.uniprot.org/uniprot/Q7ZU02 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31430272 |