| http://purl.uniprot.org/citations/31430310 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31430310 | http://www.w3.org/2000/01/rdf-schema#comment | "Methamphetamine (METH), a commonly abused drug, elevates extracellular dopamine (DA) levels by inducing DA efflux through the DA transporter (DAT). Emerging evidence in rodent models suggests that locomotor responses to a novel inescapable open field may predict behavioral responses to abused drugs; METH produces more potent stimulant effects in high responders to novelty than in low responders. We herein found that mice deficient in protein tyrosine phosphatase receptor type Z (Ptprz-KO) exhibited an enhanced behavioral response to novelty; however, METH-induced hyperlocomotion was significantly lower in Ptprz-KO than in wild-type mice when METH was administered at a non-toxic dose of 1 mg per kg body weight (bdw). Single-cell RT-PCR revealed that the majority of midbrain DA neurons expressed PTPRZ. No histological alterations were observed in the mesolimbic or nigrostriatal dopaminergic pathways in Ptprz-KO brains; however, a significant decrease was noted in brain DA turnover, suggesting functional alterations. In vivo microdialysis experiments revealed that METH-evoked DA release in the nucleus accumbens was significantly lower in Ptprz-KO mice than in wild-type mice. Consistent with this result, Ptprz-KO mice showed significantly fewer cell surface DAT as well as weaker DA uptake activity in striatal synaptosomes prepared 1 hr after the administration of METH than wild-type mice, while no significant differences were observed in the two groups treated with saline. These results indicate that the high response phenotype of Ptprz-KO mice to novelty may not be simply attributed to hyper-dopaminergic activity, and that deficits in PTPRZ reduce the effects of METH by reducing DAT activity."xsd:string |
| http://purl.uniprot.org/citations/31430310 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0221205"xsd:string |
| http://purl.uniprot.org/citations/31430310 | http://purl.uniprot.org/core/author | "Hattori S."xsd:string |
| http://purl.uniprot.org/citations/31430310 | http://purl.uniprot.org/core/author | "Sakaguchi G."xsd:string |
| http://purl.uniprot.org/citations/31430310 | http://purl.uniprot.org/core/author | "Song W.J."xsd:string |
| http://purl.uniprot.org/citations/31430310 | http://purl.uniprot.org/core/author | "Yamamoto H."xsd:string |
| http://purl.uniprot.org/citations/31430310 | http://purl.uniprot.org/core/author | "Noda M."xsd:string |
| http://purl.uniprot.org/citations/31430310 | http://purl.uniprot.org/core/author | "Noda Y."xsd:string |
| http://purl.uniprot.org/citations/31430310 | http://purl.uniprot.org/core/author | "Katsuura G."xsd:string |
| http://purl.uniprot.org/citations/31430310 | http://purl.uniprot.org/core/author | "Fujikawa A."xsd:string |
| http://purl.uniprot.org/citations/31430310 | http://purl.uniprot.org/core/author | "Nabeshima T."xsd:string |
| http://purl.uniprot.org/citations/31430310 | http://purl.uniprot.org/core/author | "Sora I."xsd:string |
| http://purl.uniprot.org/citations/31430310 | http://purl.uniprot.org/core/author | "Tanga N."xsd:string |
| http://purl.uniprot.org/citations/31430310 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31430310 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/31430310 | http://purl.uniprot.org/core/pages | "e0221205"xsd:string |
| http://purl.uniprot.org/citations/31430310 | http://purl.uniprot.org/core/title | "Mice deficient in protein tyrosine phosphatase receptor type Z (PTPRZ) show reduced responsivity to methamphetamine despite an enhanced response to novelty."xsd:string |
| http://purl.uniprot.org/citations/31430310 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/31430310 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31430310 |
| http://purl.uniprot.org/citations/31430310 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31430310 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YVD2-mappedCitation-31430310 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31430310 |
| http://purl.uniprot.org/uniprot/#_B2RXS8-mappedCitation-31430310 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31430310 |
| http://purl.uniprot.org/uniprot/#_B9EKR1-mappedCitation-31430310 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31430310 |
| http://purl.uniprot.org/uniprot/#_Q99LN6-mappedCitation-31430310 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31430310 |