| http://purl.uniprot.org/citations/31431000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31431000 | http://www.w3.org/2000/01/rdf-schema#comment | "Thimet oligopeptidase (THOP1) is thought to be involved in neuropeptide metabolism, antigen presentation, neurodegeneration, and cancer. Herein, the generation of THOP1 C57BL/6 knockout mice (THOP1-/-) is described showing that they are viable, have estrus cycle, fertility, and a number of puppies per litter similar to C57BL/6 wild type mice (WT). In specific brain regions, THOP1-/- exhibit altered mRNA expression of proteasome beta5, serotonin 5HT2a receptor and dopamine D2 receptor, but not of neurolysin (NLN). Peptidomic analysis identifies differences in intracellular peptide ratios between THOP1-/- and WT mice, which may affect normal cellular functioning. In an experimental model of multiple sclerosis THOP1-/- mice present worse clinical behavior scores compared to WT mice, corroborating its possible involvement in neurodegenerative diseases. THOP1-/- mice also exhibit better survival and improved behavior in a sepsis model, but also a greater peripheral pain sensitivity measured in the hot plate test after bradykinin administration in the paw. THOP1-/- mice show depressive-like behavior, as well as attention and memory retention deficits. Altogether, these results reveal a role of THOP1 on specific behaviors, immune-stimulated neurodegeneration, and infection-induced inflammation."xsd:string |
| http://purl.uniprot.org/citations/31431000 | http://purl.org/dc/terms/identifier | "doi:10.3390/biom9080382"xsd:string |
| http://purl.uniprot.org/citations/31431000 | http://purl.uniprot.org/core/author | "Ferro E.S."xsd:string |
| http://purl.uniprot.org/citations/31431000 | http://purl.uniprot.org/core/author | "Pesquero J.B."xsd:string |
| http://purl.uniprot.org/citations/31431000 | http://purl.uniprot.org/core/author | "Bader M."xsd:string |
| http://purl.uniprot.org/citations/31431000 | http://purl.uniprot.org/core/author | "Castro L.M."xsd:string |
| http://purl.uniprot.org/citations/31431000 | http://purl.uniprot.org/core/author | "Dale C.S."xsd:string |
| http://purl.uniprot.org/citations/31431000 | http://purl.uniprot.org/core/author | "Rioli V."xsd:string |
| http://purl.uniprot.org/citations/31431000 | http://purl.uniprot.org/core/author | "Tufik S."xsd:string |
| http://purl.uniprot.org/citations/31431000 | http://purl.uniprot.org/core/author | "Cunha F.Q."xsd:string |
| http://purl.uniprot.org/citations/31431000 | http://purl.uniprot.org/core/author | "Chagas J.R."xsd:string |
| http://purl.uniprot.org/citations/31431000 | http://purl.uniprot.org/core/author | "Iwai L.K."xsd:string |
| http://purl.uniprot.org/citations/31431000 | http://purl.uniprot.org/core/author | "Camarini R."xsd:string |
| http://purl.uniprot.org/citations/31431000 | http://purl.uniprot.org/core/author | "Guimaraes A.O."xsd:string |
| http://purl.uniprot.org/citations/31431000 | http://purl.uniprot.org/core/author | "Munhoz C.D."xsd:string |
| http://purl.uniprot.org/citations/31431000 | http://purl.uniprot.org/core/author | "Visniauskas B."xsd:string |
| http://purl.uniprot.org/citations/31431000 | http://purl.uniprot.org/core/author | "Borges V.F."xsd:string |
| http://purl.uniprot.org/citations/31431000 | http://purl.uniprot.org/core/author | "Abilio V.C."xsd:string |
| http://purl.uniprot.org/citations/31431000 | http://purl.uniprot.org/core/author | "Lima B.H.F."xsd:string |
| http://purl.uniprot.org/citations/31431000 | http://purl.uniprot.org/core/author | "Florio J.C."xsd:string |
| http://purl.uniprot.org/citations/31431000 | http://purl.uniprot.org/core/author | "Eichler R.A.S."xsd:string |
| http://purl.uniprot.org/citations/31431000 | http://purl.uniprot.org/core/author | "Franco R.D."xsd:string |
| http://purl.uniprot.org/citations/31431000 | http://purl.uniprot.org/core/author | "Gewehr M.C.F."xsd:string |
| http://purl.uniprot.org/citations/31431000 | http://purl.uniprot.org/core/author | "Llanos R.P."xsd:string |