| http://purl.uniprot.org/citations/31435636 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31435636 | http://www.w3.org/2000/01/rdf-schema#comment | "Human immunodeficiency virus (HIV) transcription is closely associated with chromatin remodeling. Retinoblastoma binding protein 4 (RBBP4) is a histone chaperone implicated in chromatin remodeling. However, the role of RBBP4 in HIV-1 infection and the underlying mechanism remain elusive. In the present study, we showed that RBBP4 plays a negative regulatory role during HIV-1 infection. RBBP4 expression was significantly increased in HIV-1-infected T cells. RBBP4 binds to the HIV-1 long terminal repeat (LTR)， represses HIV-1 LTR-mediated transcription through recruiting nuclear receptor subfamily 2 group F member 1(NR2F1) and histone deacetylase 1 and 2 (HDAC1/2) to HIV-1 LTR, and further controls local histone 3 (H3) deacetylation and chromatin compaction. Furthermore, the occupancy of RBBP4, HDAC1/2, and NR2F1 on LTR in HIV-latent J-lat cells was significantly higher than that in HIV-1-activated cells. In conclusion, our results establish RBBP4 as a new potent antiretroviral factor, which may provide theoretical basis for the treatment of HIV in the future."xsd:string |
| http://purl.uniprot.org/citations/31435636 | http://purl.org/dc/terms/identifier | "doi:10.1093/abbs/gmz082"xsd:string |
| http://purl.uniprot.org/citations/31435636 | http://purl.uniprot.org/core/author | "Cheng L."xsd:string |
| http://purl.uniprot.org/citations/31435636 | http://purl.uniprot.org/core/author | "Lu L."xsd:string |
| http://purl.uniprot.org/citations/31435636 | http://purl.uniprot.org/core/author | "Yang J."xsd:string |
| http://purl.uniprot.org/citations/31435636 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/31435636 | http://purl.uniprot.org/core/author | "Yang Z."xsd:string |
| http://purl.uniprot.org/citations/31435636 | http://purl.uniprot.org/core/author | "Wu N."xsd:string |
| http://purl.uniprot.org/citations/31435636 | http://purl.uniprot.org/core/author | "Pan K."xsd:string |
| http://purl.uniprot.org/citations/31435636 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31435636 | http://purl.uniprot.org/core/name | "Acta Biochim Biophys Sin (Shanghai)"xsd:string |
| http://purl.uniprot.org/citations/31435636 | http://purl.uniprot.org/core/pages | "934-944"xsd:string |
| http://purl.uniprot.org/citations/31435636 | http://purl.uniprot.org/core/title | "Retinoblastoma binding protein 4 represses HIV-1 long terminal repeat-mediated transcription by recruiting NR2F1 and histone deacetylase."xsd:string |
| http://purl.uniprot.org/citations/31435636 | http://purl.uniprot.org/core/volume | "51"xsd:string |
| http://purl.uniprot.org/citations/31435636 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31435636 |
| http://purl.uniprot.org/citations/31435636 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31435636 |
| http://purl.uniprot.org/uniprot/#_B4DRT0-mappedCitation-31435636 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31435636 |
| http://purl.uniprot.org/uniprot/#_Q09028-mappedCitation-31435636 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31435636 |
| http://purl.uniprot.org/uniprot/B4DRT0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31435636 |
| http://purl.uniprot.org/uniprot/Q09028 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31435636 |